尼达唑

Description

Niridazole · CAS 61-57-4 · C6H6N4O3S. UNII N116U8Y5QQ. Melting Point: 260-262 °C; Solubility: In water, 1.3X10+2 mg/L at 25 °C; LogP: log Kow = 0.95.

Identification

CAS Registry Number	61-57-4
PubChem CID	6093
Molecular formula	C6H6N4O3S
IUPAC name	1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one
UNII (FDA)	N116U8Y5QQ

Computed Descriptors

Molecular Weight	214.20
XLogP3	0.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	214.01606124
Monoisotopic Mass	214.01606124
Topological Polar Surface Area	119
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Melting Point	260-262 °C
Solubility	In water, 1.3X10+2 mg/L at 25 °C
LogP	log Kow = 0.95
LogP	0.91

Physical description & handling notes

• Yellow crystals from dimethylformamide/methanol
• Insoluble in most organic solvents; soluble in dimethylformamide
• Trade names: Ambilhar (Ciba-Geigy); Ambilhar Ciba (Biogalenica Q Farm).

Documented Uses

• THERAP CAT: Anthelmintic (Schistosoma)
• ... Obtained by reaction of /2-amino-5-nitrothiazole/ with 2- chloroethyl isocyanate followed by ring closure.
• One hundred patients with active schistosomiasis mansoni were treated with niridazole (25 mg/kg/day po for 7 days). The most serious side effects were those connected with the neuropsychic area (convulsion, hallucination, etc.). Therapeutic activity, based on repeated stool examinations, was about 90% in adults and 60% in children. Because of the side effects, as well as the long-term schedule of treatment, niridazole is not recommended for use under field conditions. ...
• Niridazole is a nitrothiazole anthelmintic agent used to treat schistosomiasis. Its antibacterial activity was found to require the presence of the nitro group; a synthetic desnitro analog was completely inactive.
• Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.
• Agents that act systemically to kill adult schistosomes.

Synonyms

Niridazole; 61-57-4; Nitrothiazole; Ambilhar; Nitrothiamidazol; Niridazolum; Ciba 32644-Ba; Niridazol; 1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one; BA 32644; 1-(5-NITRO-2-THIAZOLYL)-2-IMIDAZOLIDINONE; DTXSID6045244; NSC-136947; CIBA 32644BA; N116U8Y5QQ; BA-32644

Frequently Asked Questions

What are the CAS number and molecular formula of Niridazole?

CAS 61-57-4; molecular formula C6H6N4O3S; molecular weight — g/mol.

What other names is Niridazole known by?

Niridazole, 61-57-4, Nitrothiazole, Ambilhar, Nitrothiamidazol, Niridazolum.

What are the key physical properties of Niridazole?

Melting Point: 260-262 °C; Solubility: In water, 1.3X10+2 mg/L at 25 °C; LogP: log Kow = 0.95; LogP: 0.91.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.