马来酸诺米芬辛

马来酸诺米芬辛（CAS 24526-64-5）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• When heated decomposition it emits toxic fumes of NOx.
• 155.8 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID0023377]
• 156.2 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0023377]
• 154.65 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 155.15 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 157.41 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.
• Preparation: GB 1164192 corresp to G. Ehrhart at al., US 3577424 (1969, 1971, both to Farbwerke Hoechst)
• Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA published a notice of its determination that Merital capsules were removed from the market for safety reasons (see the Federal Register of June 17, 1986 (51 FR 21981)). Approval of the NDA for Merital capsules was withdrawn on March 20, 1992 (see the Federal Register of March 20, 1992 (57 FR 9729)). Also
• Nomifensine, introduced in 1985, is a tetrahydroisoquinoline antidepressant. /No longer approved for use in the US/
• The development of sudden fever in 6 women and one man (mean age, 64 yr) during oral nomifensine therapy at usual doses is reported. During original therapy, fever occurred within 2 wk (range, a few hr to 30 days) and sooner during a second treatment (one to 3 days). In 6 cases, the recurrence of the fever closely following the rechallenge is suggestive of a causal relationship and implies a hypersensitivity reaction.
• In humans, nomifensine has been found to mildly elevate heart rate but not to affect orthostatic blood pressure, QRS width, QT interval, or the His-bundle electrocardiogram at doses up to 200 mg/day for three weeks.

它在各数据库里的别名

Nomifensine; 24526-64-5; nomifensin; Linamiphen; (+-)-Nomifensin; (+-)-Nomifensine; Nomifensina; Nomifensinum; 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-; D,L-nomifensine; 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline; 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine; DTXSID0023377; 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine; 1LGS5JRP31; Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-

计算机算出的分子描述符

数据库摘要

nomifensine maleate · CAS 24526-64-5 · C16H18N2. UNII 1LGS5JRP31. 熔点: 180; 熔点: 179-181 °C.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。