氧苯基保泰松

Description

OXYPHENYL BUTAZONE · CAS 129-20-4 · C19H20N2O3. UNII A7D84513GV. Melting Point: 96; Solubility: 60; LogP: 2.72.

Identification

CAS Registry Number	129-20-4
PubChem CID	4641
Molecular formula	C19H20N2O3
IUPAC name	4-butyl-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione
UNII (FDA)	A7D84513GV

Computed Descriptors

Molecular Weight	324.4
XLogP3	2.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	324.14739250
Monoisotopic Mass	324.14739250
Topological Polar Surface Area	60.9
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Melting Point	96
Solubility	60
LogP	2.72
LogP	3.04
Collision Cross Section	179.21 Ų [M+H]+
Collision Cross Section	184.74 Ų [M-H]-

Physical description & handling notes

• WHITE TO YELLOWISH WHITE, CRYSTALLINE POWDER
• ODORLESS
• ANHYDROUS CRYSTALS FROM ETHER & PETROLEUM ETHER WITH MP 124-125 °C; ACIDIC REACTION; MP 96 °C; FORMS WATER-SOL SODIUM SALT; SOL IN ETHANOL, METHANOL, CHLOROFORM, BENZENE, ETHER /MONOHYDRATE/
• VERY SLIGHTLY SOL IN WATER; FREELY SOL IN ACETONE
• 163.33 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 173.24 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H400 (100%)

Documented Uses

• HAFLIGER, US PATENT 2,745,783 (1956 TO GEIGY): PFISTER, HAFLIGER, HELV CHIM ACTA 40, 395 (1957).
• OXYPHENBUTAZONE IS HYDROXY ANALOG OF PHENYLBUTAZONE & ONE OF MAJOR ACTIVE METABOLITES OF PARENT DRUG. ... OXYPHENBUTAZONE HAS SAME SPECTRUM OF ACTIVITY, THERAPEUTIC USES, INTERACTIONS, & TOXICITY AS PARENT COMPD, & IT SHARES SAME INDICATIONS, DANGERS, & CONTRAINDICATIONS FOR CLINICAL USE.
• Anti-Inflammatory Agents, Non-Steroidal; Anti-Inflammatory Agents, Topical
• EPISCLERITIS & UVEITIS ASSOC WITH RHEUMATOID ARTHRITIS HAVE SOMETIMES BEEN TREATED SUCCESSFULLY WITH...OXYPHENBUTAZONE.
• ...HAS MILD URICOSURIC EFFECT IN EXPTL ANIMALS & MAN, PROBABLY ATTRIBUTABLE TO ONE OF ITS METABOLITES.
• ...HAS MILD URICOSURIC EFFECT IN EXPTL ANIMALS & MAN... URICOSURIC EFFECT RESULTS FROM DIMINISHED TUBULAR REABSORPTION OF URIC ACID. ...CAUSES SIGNIFICANT RETENTION OF SODIUM & CHLORIDE, ACCOMPANIED BY REDN IN URINE VOL... REDUCES UPTAKE OF IODINE BY THYROID GLAND...ALSO INHIBITS ENZYMES OF KREBS CYCLE... /PHENYLBUTAZONE/

Synonyms

oxyphenbutazone; 129-20-4; Oxyphenylbutazone; Tandearil; Flogitolo; Flogoril; Frabel; Oxalid; Neo-Farmadol; Crovaril; Oxazolidin; Visubutina; Oxifenylbutazon; Oxiphenbutazone; Butapirone; Californit

Frequently Asked Questions

What are the CAS number and molecular formula of OXYPHENYL BUTAZONE?

CAS 129-20-4; molecular formula C19H20N2O3; molecular weight — g/mol.

What other names is OXYPHENYL BUTAZONE known by?

oxyphenbutazone, 129-20-4, Oxyphenylbutazone, Tandearil, Flogitolo, Flogoril.

Is OXYPHENYL BUTAZONE classified as hazardous?

Hazard statements reported: H302, H400.

What are the key physical properties of OXYPHENYL BUTAZONE?

Melting Point: 96; Solubility: 60; LogP: 2.72; LogP: 3.04.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.