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Description

Orphenadrine hydrochloride · CAS 341-69-5 · C18H23NO.ClH. UNII UBY910DUXH. Melting Point: 313 to 315 °F (NTP, 1992).

Identification

CAS Registry Number	341-69-5
PubChem CID	9568
Molecular formula	C18H23NO.ClH
IUPAC name	N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine;hydrochloride
UNII (FDA)	UBY910DUXH

Computed Descriptors

Molecular Weight	305.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Exact Mass	305.1546421
Monoisotopic Mass	305.1546421
Topological Polar Surface Area	12.5
Heavy Atom Count	21
Formal Charge	0
Complexity	260

Physical & Chemical Properties

Melting Point	313 to 315 °F (NTP, 1992)

Physical description & handling notes

• Orphenadrine hydrochloride appears as odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste. (NTP, 1992)
• greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
• >45.9 [ug/mL] (The mean of the results at pH 7.4)

GHS Hazard Classification

Reported hazard statements	H301 (97.7%)

Documented Uses

• Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
• Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
• Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
• Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2B6.
• N04AB - Ethers chemically close to antihistamines
• N04AB02 - Orphenadrine (chloride)

Synonyms

Orphenadrine hydrochloride; 341-69-5; Orphenadrine HCl; Mephenamin; Mebedrol; Mephenamin forte; Mefenamin hydrochloride; Mephenamin hydrochloride; Orfenadrin hydrochloride; Mephenamine hydrochloride; Orphenadrine (Chloride); BF 5930; BG 5930; DTXSID5025815; UBY910DUXH; NSC-82357

Frequently Asked Questions

What are the CAS number and molecular formula of Orphenadrine hydrochloride?

CAS 341-69-5; molecular formula C18H23NO.ClH; molecular weight — g/mol.

What other names is Orphenadrine hydrochloride known by?

Orphenadrine hydrochloride, 341-69-5, Orphenadrine HCl, Mephenamin, Mebedrol, Mephenamin forte.

Is Orphenadrine hydrochloride classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of Orphenadrine hydrochloride?

Melting Point: 313 to 315 °F (NTP, 1992).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.