盐酸吡格列酮

Description

Pioglitazone Hydrochloride · CAS 112529-15-4 · C19H20N2O3S. UNII X4OV71U42S. Melting Point: 193-194C; Melting Point: 183-184 °C; Melting Point: 183 - 184 °C.

Identification

CAS Registry Number	112529-15-4
PubChem CID	4829
Molecular formula	C19H20N2O3S
IUPAC name	5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
UNII (FDA)	X4OV71U42S

Computed Descriptors

Molecular Weight	356.4
XLogP3	3.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	356.11946368
Monoisotopic Mass	356.11946368
Topological Polar Surface Area	93.6
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	193-194C
Melting Point	183-184 °C
Melting Point	183 - 184 °C
Solubility	4.42e-03 g/L
LogP	2.3
LogP	3.39
Dissociation Constants	5.19

Physical description & handling notes

• Solid
• Colorless needles from dimethylformamide and water
• Colorless prisms from ethanol, MP: 193-194 °C. Soluble in dimethyl formamide; slightly soluble in ethanol; very slightly soluble in acetone, acetonitrile. Practically insoluble in water; insoluble in ether. /Pioglitazone hydrochloride/
• Practically insoluble
• Stable under recommended storage conditions. /Pioglitazone hydrochloride/
• Hazardous decomposition products formed under fire conditions: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Hydrogen chloride gas. /Pioglitazone hydrochloride/

GHS Hazard Classification

Reported hazard statements	H302, H312, H332 (16.7%), H315 (16.7%), H319 (16.7%), H335 (16.7%), H351 (16.7%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >1000
• Consumption (g per capita; approx.) in Germany (2009): 0.0122
• Consumption (g per capita) in the USA (2002): 0.0267
• Treatment of Type II diabetes mellitus
• Pioglitazone exists in two polymorphic crystal forms. Polymorph 1 is used in the manufacture of the finished drug product. The manufacture of pioglitazone consists of six steps, the last in combination with hydrochloride to yield pioglitazone hydrochloride.
• Preparation: K. Meguro, T. Fujita, European Patent Office patent 193256; eidem United States of America patent 4687777 (1986, 1987 both to Takeda)

Synonyms

Pioglitazone; 111025-46-8; Glustin; Zactos; Pioglitazona; Pioglitazonum; 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; AD-4833; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; CHEBI:8228; X4OV71U42S; U-72107; 5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione; 5-[4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]BENZYL]-2,4-THIAZOLIDINEDIONE; DTXCID1017129; DTXSID3037129

Frequently Asked Questions

What are the CAS number and molecular formula of Pioglitazone Hydrochloride?

CAS 112529-15-4; molecular formula C19H20N2O3S; molecular weight — g/mol.

What other names is Pioglitazone Hydrochloride known by?

Pioglitazone, 111025-46-8, Glustin, Zactos, Pioglitazona, Pioglitazonum.

Is Pioglitazone Hydrochloride classified as hazardous?

Hazard statements reported: H302, H312, H332, H315, H319.

What are the key physical properties of Pioglitazone Hydrochloride?

Melting Point: 193-194C; Melting Point: 183-184 °C; Melting Point: 183 - 184 °C; Solubility: 4.42e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.