盐酸普罗帕酮

Description

Propafenone HCl · CAS 34183-22-7 · C21H28ClNO3. UNII 33XCH0HOCD.

Identification

CAS Registry Number	34183-22-7
PubChem CID	36708
Molecular formula	C21H28ClNO3
IUPAC name	1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
UNII (FDA)	33XCH0HOCD

Computed Descriptors

Molecular Weight	377.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	11
Exact Mass	377.1757714
Monoisotopic Mass	377.1757714
Topological Polar Surface Area	58.6
Heavy Atom Count	26
Formal Charge	0
Complexity	368

Physical description & handling notes

• >56.7 [ug/mL] (The mean of the results at pH 7.4)
• 177.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H312 (34.4%), H332 (33.8%)

Documented Uses

• Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
• A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.

Synonyms

PROPAFENONE HYDROCHLORIDE; 34183-22-7; Propafenone HCl; Rythmol SR; Baxarytmon; Propafenon hydrochlorid; 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride; 33XCH0HOCD; 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride; NSC-758640; 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one hydrochloride; 2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone hydrochloride; 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, hydrochloride; CHEBI:8466; DTXSID101017233; RefChem:55925

Frequently Asked Questions

What are the CAS number and molecular formula of Propafenone HCl?

CAS 34183-22-7; molecular formula C21H28ClNO3; molecular weight — g/mol.

What other names is Propafenone HCl known by?

PROPAFENONE HYDROCHLORIDE, 34183-22-7, Propafenone HCl, Rythmol SR, Baxarytmon, Propafenon hydrochlorid.

Is Propafenone HCl classified as hazardous?

Hazard statements reported: H302, H312, H332.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.