培哚普利特丁胺

Description

Perindopril erbumine · CAS 107133-36-8 · C19H32N2O5. UNII Y5GMK36KGY. Solubility: 1.22e+00 g/L; LogP: 2.6.

Identification

CAS Registry Number	107133-36-8
PubChem CID	107807
Molecular formula	C19H32N2O5
IUPAC name	(2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
UNII (FDA)	Y5GMK36KGY

Computed Descriptors

Molecular Weight	368.5
XLogP3	0.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	368.23112213
Monoisotopic Mass	368.23112213
Topological Polar Surface Area	95.9
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Solubility	1.22e+00 g/L
LogP	2.6

Physical description & handling notes

• Solid
• 189.7 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID1044198]
• 190.7 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID1044198]
• 196.4 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID1044198]

GHS Hazard Classification

Reported hazard statements	H319 (100%), H336 (100%), H360 (100%), H373 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Consumption (g per capita) in France (2004): 0.00834
• For the treatment of mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.
• Perindopril is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and stable coronary artery disease. Perindopril is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Angiotensin-Converting Enzyme Inhibitors; ACE Inhibitors

Synonyms

PERINDOPRIL; 82834-16-0; Perindoprilum; McN-A-2833; S-9490; DTXSID6023440; Y5GMK36KGY; CHEBI:8024; DTXCID303440; S 9490; (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid; (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester; S9490; Pirindopril; (2S,3aS,7aS)-1-((2S)-2-(((2S)-1-ethoxy-1-oxopentan-2-yl)amino)propanoyl)octahydro-1H-indole-2-carboxylic acid; (2S,3aS,7aS)-1-[(S)-N-[(S)-1-Carboxybutyl]alanyl]hexahydro-2-indolinecarboxylic acid, 1-ethyl ester

Frequently Asked Questions

What are the CAS number and molecular formula of Perindopril erbumine?

CAS 107133-36-8; molecular formula C19H32N2O5; molecular weight — g/mol.

What other names is Perindopril erbumine known by?

PERINDOPRIL, 82834-16-0, Perindoprilum, McN-A-2833, S-9490, DTXSID6023440.

Is Perindopril erbumine classified as hazardous?

Hazard statements reported: H319, H336, H360, H373.

What are the key physical properties of Perindopril erbumine?

Solubility: 1.22e+00 g/L; LogP: 2.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.