Prasugrel

Description

Prasugrel · CAS 150322-43-3 · C20H20FNO3S. UNII 34K66TBT99. Solubility: 2.37e-03 g/L; LogP: 3.536.

Identification

CAS Registry Number	150322-43-3
PubChem CID	6918456
Molecular formula	C20H20FNO3S
IUPAC name	[5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl] acetate
UNII (FDA)	34K66TBT99

Computed Descriptors

Molecular Weight	373.4
XLogP3	3.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	373.11479284
Monoisotopic Mass	373.11479284
Topological Polar Surface Area	74.9
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Solubility	2.37e-03 g/L
LogP	3.536

Physical description & handling notes

• Solid
• MF: C20H20FN0SS.HCl. MW: 409.90. White to practically white solid. Soluble at pH 2, slightly soluble at pH 3 to 4, and practically insoluble at pH 6 to 7.5. Dissolves freely in methanol and is slightly soluble in 1- and 2-propanol and acetone. It is practically insoluble in diethyl ether and ethyl acetate. /Prasugrel hydrochloride/
• Prasugrel is a thienopyridine ADP receptor inhibitors which inhibits platelet aggregation by irreversibly binding to P2Y12 receptors.
• Oral: Tablets: 5 mg (of prasugrel), Effient, Eli Lilly and Company (also promoted by Daiichi Sankyo, Inc.); 10 mg (of prasugrel), Effient, Eli Lilly and Company (also promoted by Daiichi Sankyo, Inc.).

Regulatory Status

GHS notification summary	1.8% (1 / 56)

GHS Hazard Classification

GHS notification summary	1.8% (1 / 56)
Reported hazard statements	H302 (94.6%), H370 (94.6%), H373 (94.6%), H411 (96.4%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Prasugrel is an inhibitor of platelet aggregation that is used to decrease the risk of myocardial infarction and stroke in patients with acute coronary syndromes. Prasugrel has been linked to mild and transient serum enzyme elevations during therapy and to rare instances of hypersensitivity reactions accompanied by mild liver injury.
• Breastfeeding; Lactation; Milk, Human; Platelet Aggregation Inhibitors
• Purinergic P2Y Receptor Antagonists
• Safety and efficacy have not been established in pediatric patients.

Synonyms

Prasugrel; 150322-43-3; CS-747; 5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate; LY-640315; prasugrelum; NSC-759625; 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate; CHEBI:87723; HSDB 7995; 34K66TBT99; Ethanone, 2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-; DTXSID70861544; 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4H,5H,6H,7H-thieno[3,2-c]pyridin-2-yl acetate; Ethanone, 2-(2-(acetyloxy)-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-1-cyclopropyl-2-(2-fluorophenyl)-; 5-(2-CYCLOPROPYL-1-(2-FLUOROPHENYL)-2-OXOETHYL)-4,5,6,7-TETRAHYDROTHIENO(3,2-C)PYRIDIN-2-YL ACETATE

Frequently Asked Questions

What are the CAS number and molecular formula of Prasugrel?

CAS 150322-43-3; molecular formula C20H20FNO3S; molecular weight — g/mol.

What other names is Prasugrel known by?

Prasugrel, 150322-43-3, CS-747, 5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate, LY-640315, prasugrelum.

Is Prasugrel classified as hazardous?

1.8% of GHS notifications report no hazard classification (1 of 56).

What are the key physical properties of Prasugrel?

Solubility: 2.37e-03 g/L; LogP: 3.536.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.