酚妥拉明

酚妥拉明（CAS 50-60-2）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Solid
• Crystals
• Bitter crystals; MP: 239-240 °C. One gram dissolves in 50 mL water, in 70 mL alcohol. Very slightly soluble in chloroform. Practically insoluble in acetone, ethyl acetate. pH of 1% aqueous solution 4.5 to 5.5. Aqueous solutions cannot be stored. /Phentolamin hydrochloride/
• Following reconstitution of the commercially available lyophilized powder with sterile water for injection to a concentration of 5 mg/mL, phentolamine mesylate injection is stable for 48 hours at room temperature or 1 week at 2-8 °C; however, the manufacturer recommends that the reconstituted injection be used immediately and not stored.
• 166.27 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 156.25 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of Raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease
• To relieve pseudo-obstruction of the bowel in patients with pheochromocytoma; to prevent dermal necrosis after inadvertent extravasation of an alpha-receptor antagonist; for treatment of hypertensive crisis that follow the abrupt withdrawal of clonidine or that may result from the ingestion of tyramine-containing food during the use of nonselective MAO inhibitors.
• THERAPEUTIC CATEGORY: Antihypertensive in treatment of pheochromocytoma; diagnostic aid (pheochromocytoma). In treatment of male erectile dysfunction.
• m-(p-Toluidino)phenol is refluxed with 2-chloromethylimidazoline hydrochloride and the resulting phentolamine base treated with an equimolar protion of methanesulfonic acid. /Phentolamine mesylate/
• No longer widely used because of its side effects /which include arrhythmia and tachycardia/.
• When used intravenously or intramuscularly, phentolamine is used to prevent or control hypertensive episodes that may occur in a patient with pheochromocytoma due to stress or manipulation during preoperative preparation and surgical excision. It is also used to prevent or treat dermal necrosis and sloughing following intravenous administration or extravasation of norepinephrine. It may be used to diagnose pheochromocytoma by the phentolamine-blocking test. Submucosal injection of phentolamine is indicated for the

它在各数据库里的别名

phentolamine; 50-60-2; Regitin; Dibasin; Fentolamin; Fentolamina; Rogitine; Phentolaminum; C 7337 Ciba; Phentolamin; 2-(N-(m-Hydroxyphenyl)-p-toluidinomethyl)imidazoline; C 7337; DTXSID4023462; 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline; 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol; 2-((N-(m-Hydroxyphenyl)-p-toluidino)methyl)-2-imidazoline

计算机算出的分子描述符

数据库摘要

phentolamine · CAS 50-60-2 · C17H19N3O. UNII Z468598HBV. 熔点: 181; 熔点: 175 °C; 熔点: 174.5 °C.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。