帕唑帕尼

帕唑帕尼（CAS 444731-52-6）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Based on the stability data a shelf-life of 24 months will be applied to the product, with no special storage conditions requirements.
• Stable if stored as directed; avoid strong oxidizing agents. /Pazopanib hydrochloride/
• Thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides. /Pazopanib hydrochloride/
• White to slightly yellow solid. Practically insoluble above pH 4 in aqueous media/Pazopanib hydrochloride/
• Oral: Tablets, film-coated: 200 mg (of pazopanib), Votrient (GlaxoSmithKline). /Pazopanib hydrochloride/

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• THERAPEUTIC CATEGORY: Antineoplastic
• Preparation: A. Boloor et al., World Intellectual Property Organization patent 02059110 (2002 to Glaxo); eidem, United States of America patent 7105530 (2006 to SKB).
• The manufacturing process is a standard wet granulation process and consists of the following steps: granulation; milling; drying; blending and compression. The tablets are then film-coated.
• Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
• Pazopanib is a multi-kinase inhibitor active against vascular endothelial growth factor receptors-1, -2 and -3 that is used in the therapy of advanced renal cell carcinoma and soft tissue sarcomas. Pazopanib therapy is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe and even fatal cases of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors;

它在各数据库里的别名

Pazopanib; 444731-52-6; GW786034; 5-((4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide; pazopanibum; DTXSID8048733; 7RN5DR86CK; NSC-752782; GW780604; GW-780604; 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide; DTXCID1028659; CHEBI:71219; Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-; 5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide; Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-

计算机算出的分子描述符

数据库摘要

Pazopanib · CAS 444731-52-6 · C21H23N7O2S. UNII 7RN5DR86CK. LogP: 3.3.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。