前列腺素 F(2)(α) 三盐

Description

prostaglandin F(2)(alpha) tris salt · CAS 38562-01-5 · C24H45NO8. UNII CT6BBQ5A68. Melting Point: 100-101; Solubility: 0.2; LogP: -0.12.

Identification

CAS Registry Number	38562-01-5
PubChem CID	5282415
Molecular formula	C24H45NO8
IUPAC name	2-amino-2-(hydroxymethyl)propane-1,3-diol;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
UNII (FDA)	CT6BBQ5A68

Computed Descriptors

Molecular Weight	475.6
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	15
Exact Mass	475.31451739
Monoisotopic Mass	475.31451739
Topological Polar Surface Area	185
Heavy Atom Count	33
Formal Charge	0
Complexity	486

Physical & Chemical Properties

Melting Point	100-101
Solubility	0.2
LogP	-0.12

Physical description & handling notes

• Dinoprost tromethamine is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2_alpha. Prostaglandin F2_alpha has several pharmacologic effects on the female reproductive system, including stimulation of myometrial activity, relaxation of the cervix, inhibition of steroidogenesis by corpora lutea, and can potentially lyse corpora lutea.

GHS Hazard Classification

Reported hazard statements	H302 (100%), H319 (40.8%), H360 (97.2%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography.
• Non-steroidal chemical compounds with abortifacient activity.
• Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
• Slowly absorbed from the amniotic fluid into systemic circulation.
• Enzymatic dehydrogenation primarily in the maternal lungs and also in the liver.

Synonyms

dinoprost tromethamine; 38562-01-5; Dinoprost trometamol; Prostin F2 alpha; PGF2alpha THAM; Lutalyse; PGF2-alpha tham; Prostaglandin F2alpha tham; Prostaglandin F2-alpha THAM; Prostamate; Prostaglandin F2a tromethamine; PGF2A THAM; U-14,583E; PGF2ALPHA-THAM; DTXSID1045582; CT6BBQ5A68

Frequently Asked Questions

What are the CAS number and molecular formula of prostaglandin F(2)(alpha) tris salt?

CAS 38562-01-5; molecular formula C24H45NO8; molecular weight — g/mol.

What other names is prostaglandin F(2)(alpha) tris salt known by?

dinoprost tromethamine, 38562-01-5, Dinoprost trometamol, Prostin F2 alpha, PGF2alpha THAM, Lutalyse.

Is prostaglandin F(2)(alpha) tris salt classified as hazardous?

Hazard statements reported: H302, H319, H360.

What are the key physical properties of prostaglandin F(2)(alpha) tris salt?

Melting Point: 100-101; Solubility: 0.2; LogP: -0.12.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.