盐酸丙卡巴肼

Description

procarbazine hydrochloride · CAS 366-70-1 · C12H19N3O. UNII 35S93Y190K. Melting Point: 223; Melting Point: 223 °C; Solubility: 1420.

Identification

CAS Registry Number	366-70-1
PubChem CID	4915
Molecular formula	C12H19N3O
IUPAC name	4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide
UNII (FDA)	35S93Y190K

Computed Descriptors

Molecular Weight	221.30
XLogP3	0.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	221.152812238
Monoisotopic Mass	221.152812238
Topological Polar Surface Area	53.2
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Melting Point	223
Melting Point	223 °C
Solubility	1420
Solubility	2.28e-01 g/L
Vapor Pressure	8.4X10-7 mm Hg @ 25 °C /Estimated/
LogP	0.06
LogP	log Kow = 0.06
LogP	2.6
Dissociation Constants	pKa = 6.6

Physical description & handling notes

• Solid
• In water, 1,400 mg/L @ 25 °C /Estimated/
• Henry's Law constant = 8.9X10-15 atm-cu m/mole @ 25 °C /Estimated/
• Procarbazine hydrochloride is unstable in aqueous solution. /Procarbazine hydrochloride/
• 155.9 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID4021189]
• MW: 257.77. Crystals from methanol, mp 223-226 °C. /Hydrochloride/

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
• p-toluic acid + methyl hydrazine + isopropylamine (side-chain bromination/amine formation/amide formation).
• (1976) NOT PRODUCED COMMERCIALLY IN US
• (1978) NOT PRODUCED COMMERCIALLY IN US

Synonyms

procarbazine; 671-16-9; Procarbazin; Ibenzmethyzin; Procarbazina; Procarbazinum; Procarbacine; N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine; p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide; 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine; N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide; 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine; 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide; Ro 4-6467; N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide; N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide

Frequently Asked Questions

What are the CAS number and molecular formula of procarbazine hydrochloride?

CAS 366-70-1; molecular formula C12H19N3O; molecular weight — g/mol.

What other names is procarbazine hydrochloride known by?

procarbazine, 671-16-9, Procarbazin, Ibenzmethyzin, Procarbazina, Procarbazinum.

What are the key physical properties of procarbazine hydrochloride?

Melting Point: 223; Melting Point: 223 °C; Solubility: 1420; Solubility: 2.28e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.