普纳替尼

普纳替尼（CAS 943319-70-8）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Stable if stored as directed; avoid strong oxidizing agents
• Dangerous products of decomposition: thermal ecomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.
• 2.77 and 7.8
• Most amides hydrolyze to acids extremely slowly at 25 °C and pH 7 with half-lives measured in centuries.
• Off-white to yellow powder. MW: 569.02. pKa1 = 2.77; pKa2 = 7.8. 溶解度: 7790, 3.44, and 0.16 ug/mL in pH 1.7, 2.7, and 7.5 buffers /Ponatinib hydrochloride/
• Oral: Tablets, film-coated: 15 or 45 mg (of ponatinib) Iclusig (Ariad).

这个物质在各数据库里的编号

数据库记载的用途

• Antineoplastic Agents; Protein Kinase Inhibitors
• Ponatinib is a tyrosine kinase receptor inhibitor that is used in the therapy of refractory chronic myelogenous leukemia (CML) positive for the Philadelphia chromosome. Ponatinib is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
• Iclusig (ponatinib) is a kinase inhibitor indicated for the: Treatment of adult patients with T315I-positive chronic myeloid leukemia (CML) (chronic phase, accelerated phase, or blast phase) and T315I-positive Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL). /Included in US product label/
• Ponatinib may cause fetal harm; the drug has been shown to be embryotoxic and fetotoxic in animals. There are no adequate and well-controlled studies in pregnant women. Pregnancy should be avoided during therapy. If used during pregnancy or if the patient becomes pregnant while receiving ponatinib, the patient should be apprised of the potential fetal hazard.
• For more Drug Warnings (Complete) data for Ponatinib (22 total), please visit the HSDB record page.

它在各数据库里的别名

PONATINIB; 943319-70-8; AP24534; AP 24534; AP-24534; ponatinibum; 4340891KFS; CHEBI:78543; DTXSID50241426; RefChem:58011; DTXCID50163917; L01XE24; 851-222-7; Ponatinib (AP24534); MFCD17215203; CHEMBL1171837

计算机算出的分子描述符

数据库摘要

Ponatinib · CAS 943319-70-8 · C29H27F3N6O. UNII 4340891KFS.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。