普卡那肽

普卡那肽（CAS 467426-54-6）的公开数据库记录，列此仅供独立核对。

物理形态与操作说明

• Amorphous, white to off-white powder
• Soluble in water
• 16 amino acid peptide
• Food Effect Subjects who received either a low-fat, low calorie (LF-LC) meal or a high fat, high calorie (HF-HC) meal reported looser stools than fasted subjects up to 24 hours after a single dose of 9 mg (3 times the recommended dose). In clinical studies, Plecanatide was administered with or without food.
• Oral: 30 mg tablets, Trulance

这个物质在各数据库里的编号

数据库记载的用途

• Guanylyl Cyclase C Agonists; Gastrointestinal Agents
• Plecanatide is indicated for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adult patients.
• Plecanatide is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for treatment of chronic constipation and irritable bowel syndrome. Plecanatide has not been linked to serum enzyme elevations during treatment or to episodes of clinically apparent liver injury.
• Breast Feeding; Lactation; Milk, Human; Gastrointestinal Agents; Peptides; Guanylyl Cyclase C Agonists; Laxatives
• Trulance is indicated in adults for the treatment of: chronic idiopathic constipation (CIC); Irritable bowel syndrome with constipation (IBS-C). /Included in US product label/
• /BOXED WARNING/ WARNING: RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS. Trulance is contraindicated in patients less than 6 years of age; in nonclinical studies in young juvenile mice administration of a single oral dose of plecanatide caused deaths due to dehydration. Avoid use of Trulance in patients 6 years to less than 18 years of age. The safety and effectiveness of Trulance have not been established in patients less than 18 years of age.

它在各数据库里的别名

PLECANATIDE; Trulance; 467426-54-6; Guanilib; plecanatida; 7IK8Z952OK; SP-304 (SYNERGY); DTXSID60196933; (3-Glutamic acid(D>E))human uroguanylin; [3-glutamic acid(D>E)]human uroguanylin; plecanatidum; RefChem:56535; Trulance Immediate release; A06AX07; DTXCID00119424; Plecanatide [USAN:INN]

计算机算出的分子描述符

数据库摘要

Plecanatide · CAS 467426-54-6 · C65H104N18O26S4. UNII 7IK8Z952OK.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。