帕瑞瑞韦

Description

Paritaprevir · CAS 1216941-48-8 · C40H43N7O7S. UNII OU2YM37K86.

Identification

CAS Registry Number	1216941-48-8
PubChem CID	45110509
Molecular formula	C40H43N7O7S
IUPAC name	(1S,4R,6S,7Z,14S,18R)-N-cyclopropylsulfonyl-14-[(5-methylpyrazine-2-carbonyl)amino]-2,15-dioxo-18-phenanthridin-6-yloxy-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxamide
UNII (FDA)	OU2YM37K86

Computed Descriptors

Molecular Weight	765.9
XLogP3	4.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	765.29446791
Monoisotopic Mass	765.29446791
Topological Polar Surface Area	198
Heavy Atom Count	55
Formal Charge	0

Physical description & handling notes

• At concentrations approximately 6 and 1.8 times the therapeutic concentrations of paritaprevir and ombitasvir, the combination did not prolong QTc to any clinically relevant extent.

Documented Uses

• When used within the fixed-dose combination product with [DB09296], [DB09183], and [DB00503] as the FDA-approved product Viekira Pak, paritaprevir is indicated for the treatment of HCV genotype 1b without cirrhosis or with compensated cirrhosis, and when combined with [DB00811] for the treatment of HCV genotype 1a without cirrhosis or with compensated cirrhosis. When used within the fixed-dose combination product with [DB09296] and [DB00503] as the FDA- and Health Canada-approved product Technivie, paritaprevir is
• Breast Feeding; Lactation; Milk, Human; Antiviral Agents; Protease Inhibitors
• Mechanisms of Action [MoA] - HCV NS3/4A Protease Inhibitors
• Established Pharmacologic Class [EPC] - Hepatitis C Virus NS3/4A Protease Inhibitor
• Mechanisms of Action [MoA] - Organic Anion Transporting Polypeptide 1B1 Inhibitors
• Mechanisms of Action [MoA] - Breast Cancer Resistance Protein Inhibitors

Synonyms

Paritaprevir; 1216941-48-8; Veruprevir; ABT-450; Veruprevir anhydrous; ABT450; OU2YM37K86; ABT 450; DTXSID601027922; VIEKIRAX COMPONENT PARITAPREVIR; CHEBI:85188; empty; paritaprevirum; RefChem:170090; DTXCID501513483; 1221573-85-8

Frequently Asked Questions

What are the CAS number and molecular formula of Paritaprevir?

CAS 1216941-48-8; molecular formula C40H43N7O7S; molecular weight — g/mol.

What other names is Paritaprevir known by?

Paritaprevir, 1216941-48-8, Veruprevir, ABT-450, Veruprevir anhydrous, ABT450.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.