盐酸帕纳替尼

Description

Ponatinib hydrochloride · CAS 1114544-31-8 · C29H28ClF3N6O. UNII 96R6PU3D8J.

Identification

CAS Registry Number	1114544-31-8
PubChem CID	46908927
Molecular formula	C29H28ClF3N6O
IUPAC name	3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride
UNII (FDA)	96R6PU3D8J

Computed Descriptors

Molecular Weight	569.0
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	568.1965217
Monoisotopic Mass	568.1965217
Topological Polar Surface Area	65.8
Heavy Atom Count	40
Formal Charge	0
Complexity	910

GHS Hazard Classification

Reported hazard statements	H301 (100%), H302 (50%), H351 (50%), H360 (50%), H361 (50%), H372 (100%), H410 (50%)

Documented Uses

• Iclusig (Ponatinib Hydrochloride)
• Ponatinib hydrochloride is approved for use in adults to treat:
• • Acute lymphoblastic leukemia that is Philadelphia chromosomepositive. It is used:
• • With chemotherapy in patients whose cancer is newly diagnosed.¹
• • Alone in patients whose cancer has a T315I mutation or cannot be treated with other kinase inhibitors.
• • Chronic myelogenous leukemia (CML). It is used:

Synonyms

Ponatinib hydrochloride; 1114544-31-8; Iclusig; AP 24534 hydrochloride; AP24534 HCL; 96R6PU3D8J; AP-24534 HCl; CHEBI:191940; DTXSID50149655; RefChem:58012; DTXCID0072146; Ponatinib HCl; Ponatinib Mono-hydrochloride; Ponatinib hydrochloride [USAN]; Ponatinib (HCl salt); Ponatinib (hydrochloride)

Frequently Asked Questions

What are the CAS number and molecular formula of Ponatinib hydrochloride?

CAS 1114544-31-8; molecular formula C29H28ClF3N6O; molecular weight — g/mol.

What other names is Ponatinib hydrochloride known by?

Ponatinib hydrochloride, 1114544-31-8, Iclusig, AP 24534 hydrochloride, AP24534 HCL, 96R6PU3D8J.

Is Ponatinib hydrochloride classified as hazardous?

Hazard statements reported: H301, H302, H351, H360, H361.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.