普罗替林

普罗替林（CAS 438-60-8）的公开数据库记录，列此仅供独立核对。

物理形态与操作说明

• Solid
• 169-171 °C (Protriptyline HCl)
• Max absorption 290 nm (e= 13,311); MP: 169-171 °C; crystals from isopropanol- ethyl ether /hydrochloride/
• 169 - 171 °C (protriptyline hydrochloride)
• SOL: 1 G IN ABOUT 2 ML WATER, ABOUT 2 ML METHANOL, ABOUT 2.3 ML CHLOROFORM, ABOUT 4 ML ALCOHOL; PRACTICALLY INSOL IN ETHER /HYDROCHLORIDE/
• Freely sol in water /hydrochloride/

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• For the treatment of depression.
• Engelhardt, Christy, Belgian patent 617,967 (1962 to Merck & Co) CA 59, 517f (1963); Tishler et al, US patent 3,244,748 & 3,271,451 (both 1966 to Merck & Co); Engelhardt et al, J Med Chem 11, 325 (1968).
• Protriptyline hydrochloride is a tricyclic antidepressant used to improve mood in people with depression. It is also used for anxiety. Protriptyline was first patented in 1962, and it is sold under many brand names. It is an amine with the empirical formula of CHN. It is a more potent antidepressant and has fewer sedative and tranquilizing effects than other TCAs.
• Protriptyline is a tricyclic antidepressant that was previously widely used in the therapy of major depression. Most of the tricyclic antidepressants have been shown to cause a low rate of mild and transient serum enzyme elevations and rare cases of clinically apparent acute cholestatic liver injury. The potential hepatotoxicity specifically of protriptyline, however, has not been well defined.
• Breast Feeding; Lactation; Milk, Human; Antidepressive Agents; Antidepressive Agents, Tricyclic
• Protriptyline (Class: Stimulants, Added Date: 10-1998)

它在各数据库里的别名

protriptyline; Protryptyline; Amimetilina; 438-60-8; Triptil; Protriptilina; Protriptylinum; 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene; N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine; N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine; 5-(3-Methylaminopropyl)-5H-Dibenzo[a,d]cycloheptene; N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine; 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine; N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine; 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene; 4NDU154T12

计算机算出的分子描述符

数据库摘要

protriptyline · CAS 438-60-8 · C19H21N. UNII 4NDU154T12. 溶解度: 1.04; 溶解度: 2.31e-04 g/L; LogP: 4.7.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。