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Description

Ropivacaine · CAS 84057-95-4 · C17H26N2O. UNII 7IO5LYA57N. Solubility: 53.8; Solubility: 2.53e-01 g/L; LogP: 2.9.

Identification

CAS Registry Number	84057-95-4
PubChem CID	175805
Molecular formula	C17H26N2O
IUPAC name	(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
UNII (FDA)	7IO5LYA57N

Computed Descriptors

Molecular Weight	274.4
XLogP3	2.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	274.204513457
Monoisotopic Mass	274.204513457
Topological Polar Surface Area	32.3
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Solubility	53.8
Solubility	2.53e-01 g/L
LogP	2.9
LogP	2.89
Dissociation Constants	8.07

Physical description & handling notes

• Solid
• In contrast to most other local anesthetics, the presence of [epinephrine] does not affect the time of onset, duration of action, or the systemic absorption of ropivacaine.

GHS Hazard Classification

Reported hazard statements	H302 (86.7%), H315 (66.7%), H319 (66.7%), H332 (60%), H412 (73.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >500
• Consumption (g per capita; approx.) in Germany (2009): 0.00611
• Used in obstetric anesthesia and regional anesthesia for surgery. Ropivacaine is indicated for local anaesthesia including infiltration, nerve block, epidural and intrathecal anaesthesia in adults and children over 12 years. It is also indicated for peripheral nerve block and caudal epidural in children 1-12 years for surgical pain. It is also sometimes used for infiltration anaesthesia for surgical pain in children.
• Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.
• Anesthetics are classified as amide and ester local anesthetics. Ropivacaine is an amide anesthetic.
• Breast Feeding; Lactation; Milk, Human; Anesthetics, Local

Synonyms

Ropivacaine; 84057-95-4; (S)-Ropivacaine; Ropivacaina; Ropivacainum; (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide; Ropivicaine; 7IO5LYA57N; TLC590; (-)-1-Propyl-2',6'-pipecoloxylidide; TLC-590; L-N-n-propylpipecolic acid-2,6-xylidide; CHEBI:8890; (S)-(-)-1-propyl-2',6'-pipecoloxylidide; DTXSID4040187; 1-propyl-2',6'-pipecoloxylidide

Frequently Asked Questions

What are the CAS number and molecular formula of Ropivacaine?

CAS 84057-95-4; molecular formula C17H26N2O; molecular weight — g/mol.

What other names is Ropivacaine known by?

Ropivacaine, 84057-95-4, (S)-Ropivacaine, Ropivacaina, Ropivacainum, (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide.

Is Ropivacaine classified as hazardous?

Hazard statements reported: H302, H315, H319, H332, H412.

What are the key physical properties of Ropivacaine?

Solubility: 53.8; Solubility: 2.53e-01 g/L; LogP: 2.9; LogP: 2.89.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.