盐酸雷诺嗪

Description

Ranolazine HCl · CAS 95635-56-6 · C24H33N3O4. UNII A6IEZ5M406. Boiling Point: 624.1; Melting Point: 120-124; Solubility: <1 mg/ml.

Identification

CAS Registry Number	95635-56-6
PubChem CID	56959
Molecular formula	C24H33N3O4
IUPAC name	N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
UNII (FDA)	A6IEZ5M406

Computed Descriptors

Molecular Weight	427.5
XLogP3	2.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	427.24710654
Monoisotopic Mass	427.24710654
Topological Polar Surface Area	74.3
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Boiling Point	624.1
Melting Point	120-124
Solubility	<1 mg/ml
Solubility	1.10e-01 g/L
LogP	2.07
LogP	1.6
Dissociation Constants	2.2

Physical description & handling notes

• Solid
• White to off-white solid
• Soluble in dichloromethane, methanol; sparingly soluble in tetrahydrofuran, ethanol, acetonitrile, acetone; slightly soluble in ethyl acetate, isopropanol, toluene, ethyl ether; very slightly soluble in water
• 205.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 204.15 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 203.66 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	8.3% (1 / 12)

GHS Hazard Classification

GHS notification summary	8.3% (1 / 12)
Reported hazard statements	H301 (16.7%), H302 (66.7%), H315 (25%), H319 (16.7%), H335 (25%), H336 (25%), H361 (25%), H373 (16.7%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >750
• Consumption (g per capita; approx.) in Germany (2009): 0.00916
• Preparation: A. F. Kluge et al., EP 126449; eidem, US 4567264 (1984, 1986 both to Syntex)
• Chronic angina is a common cardiovascular disorder that affects millions of patients worldwide. Chronic angina causes significant disability and inhibits activities of daily living. Ranolazine has been approved by the US Food and Drug Administration (FDA) for the treatment of chronic stable angina.
• Ranolazine is a unique, orally available antiangina agent. Chronic ranolazine therapy has not been associated with serum enzyme elevations, but has been linked to rare cases of mild, clinically apparent liver injury.
• Enzyme Inhibitors; Angina Pectoris/drug therapy

Synonyms

RANOLAZINE; 95635-55-5; Ranexa; CVT-303; RAN D; Ran4; renolazine; RS-43285-003; (+-)-Ranolazine; ASPRUZYO; Ranolazina; DTXSID3045196; NSC-759100; A6IEZ5M406; N-(2,6-DIMETHYLPHENYL)-4-[2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETAMIDE; DTXCID1025196

Frequently Asked Questions

What are the CAS number and molecular formula of Ranolazine HCl?

CAS 95635-56-6; molecular formula C24H33N3O4; molecular weight — g/mol.

What other names is Ranolazine HCl known by?

RANOLAZINE, 95635-55-5, Ranexa, CVT-303, RAN D, Ran4.

Is Ranolazine HCl classified as hazardous?

8.3% of GHS notifications report no hazard classification (1 of 12).

What are the key physical properties of Ranolazine HCl?

Boiling Point: 624.1; Melting Point: 120-124; Solubility: <1 mg/ml; Solubility: 1.10e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.