拉替拉韦

Description

Raltegravir · CAS 518048-05-0 · C20H21FN6O5. UNII 22VKV8053U.

Identification

CAS Registry Number	518048-05-0
PubChem CID	54671008
Molecular formula	C20H21FN6O5
IUPAC name	N-[2-[4-[(4-fluorophenyl)methylcarbamoyl]-5-hydroxy-1-methyl-6-oxopyrimidin-2-yl]propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide
UNII (FDA)	22VKV8053U

Computed Descriptors

Molecular Weight	444.4
XLogP3	1.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Exact Mass	444.15574595
Monoisotopic Mass	444.15574595
Topological Polar Surface Area	150
Heavy Atom Count	32
Formal Charge	0

Physical description & handling notes

• White to off-white powder; soluble in water; slightly soluble in methanol; very slightly soluble in ethanol and acetonitrile; insoluble in isopropanol /Ratlegarvir potassium/

Regulatory Status

GHS notification summary	100% (2 / 2)

GHS Hazard Classification

GHS notification summary	100% (2 / 2)

Documented Uses

• Use (kg; approx.) in Germany (2009): >500
• Consumption (g per capita; approx.) in Germany (2009): 0.00611
• For the treatment of HIV-1 infection in conjunction with other antiretrovirals.
• Raltegravir is an integrase inhibitor, the first of the class of antiviral agents active against the human immunodeficiency virus (HIV) that targets the viral integrase. Raltegravir is used in combination with other antiretroviral agents in the treatment of HIV infection. Raltegravir has not been linked convincingly to serum aminotransferase elevations during therapy or to episodes of acute, clinically apparent liver injury.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents; Anti-HIV Agents; Anti-Retroviral Agents; HIV Integrase Inhibitors
• Antiretrovirals > Integrase inhibitors

Synonyms

Raltegravir; 518048-05-0; MK-0518; MK0518; raltegravirum; DTXSID2048660; MK 0518; CHEBI:82960; 22VKV8053U; DTXCID5028586; L000900612; L-000900612; RefChem:55964; J05AX08; 0518, MK; Raltegravir (MK-0518)

Frequently Asked Questions

What are the CAS number and molecular formula of Raltegravir?

CAS 518048-05-0; molecular formula C20H21FN6O5; molecular weight — g/mol.

What other names is Raltegravir known by?

Raltegravir, 518048-05-0, MK-0518, MK0518, raltegravirum, DTXSID2048660.

Is Raltegravir classified as hazardous?

100% of GHS notifications report no hazard classification (2 of 2).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.