醋酸罗沙替丁

醋酸罗沙替丁（CAS 78628-28-1）的公开数据库记录，列此仅供独立核对。

物理形态与操作说明

• Solid
• 145-146 for HCl salt
• 145 - 146 (hydrochloride salt)
• Roxatidine acetate suppresses the effect of histamine on the parietal cells of the stomach (H2-receptor antagonist). This suppressive action is dose-dependent. As a result, the production and secretion, particularly of gastric acid, are reduced. Roxatidine acetate has no antiandrogenic effects and does not influence drug-metabolizing enzymes in the liver.

这个物质在各数据库里的编号

数据库记载的用途

• For the treatment of disorders of the upper gastro-intestinal region that are due to an excess of hydrochloric acid in the gastric juice, i.e. duodenal ulcers, benign gastric ulcers. Also for prophylaxis of recurrent gastric and duodenal ulcers
• Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
• Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
• Well absorbed orally (80–90% bioavailability).
• Roxatidine acetate is rapidly metabolised to the primary, active desacetyl metabolite.
• Roxatidine acetate Action Pathway

它在各数据库里的别名

ROXATIDINE ACETATE; 78628-28-1; Pifatidine; ZUP3LSD0DO; DTXSID2048325; ((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)carbamoyl)methyl acetate; ({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}carbamoyl)methyl acetate; RefChem:930911; DTXCID7028300; Aceroxatidine; Roxane; [2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate; 2-Oxo-2-((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)amino)ethyl acetate; Aceroxatidine; Pifatidine; Acetamide, 2-(acetyloxy)-N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-; Roxatidinum [Latin]

计算机算出的分子描述符

数据库摘要

Roxatidine acetate · CAS 78628-28-1 · C19H28N2O4. UNII ZUP3LSD0DO.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。