罗泊替尼

罗泊替尼（CAS 1802220-02-5）的公开数据库记录，列此仅供独立核对。

这个物质在各数据库里的编号

数据库记载的用途

• Repotrectinib is indicated for the treatment of adult patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC). It is also indicated in patients ≥12 years of age and older with neurotrophic tyrosine receptor kinase (NTRK) gene fusion-positive solid tumors which are locally advanced, metastatic, or where surgical resection is likely to result in severe morbidity, and who have experienced disease progression following treatment or have no satisfactory alternative.
• Repotrectinib is a small molecule inhibitor of the proto-oncogene tyrosine-protein kinase ROS1 and of tropomyosin receptor tyrosine kinases (TRK-A, -B and -C) and is used to treat adults with non-small cell lung cancer. Repotrectinib is associated with a moderate rate of mild transient elevations in serum aminotransferase levels during therapy but has not been linked to episodes of clinically apparent liver injury with jaundice.
• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
• Repotrectinib is approved to treat:
• • Non-small cell lung cancer that has spread and has an abnormal ROS1 gene. It is used in adults.
• • Solid tumors that have an NTRK gene fusion. It is used in adults and children aged 12 years and older whose cancer has spread or cannot be removed by surgery and got worse after other treatment or cannot be treated with other therapies.¹

它在各数据库里的别名

Repotrectinib; 1802220-02-5; TPX-0005; Augtyro; 08O3FQ4UNP; repotrectinibum; (3R,6S,)-45-FLUORO-3,6-DIMETHYL-5-OXA-2,8-DIAZA-1(5,3)-PYRAZOLO(1,5-A)PYRIMIDINA-4(1,2)-BENZENANONAPHAN-9-ONE; (3R,6S,)-45-Fluoro-3,6-dimethyl-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenanonaphan-9-one; RefChem:178876; Multikinase Inhibitor TPX-0005; Multi-kinase Inhibitor TPX-0005; ALK/ROS1/NTRK/SRC/FAK Multikinase Inhibitor TPX-0005; Ropotrectinib; Repotrectinib [USAN]; TPX0005; Repotrectinib(TPX-005)

计算机算出的分子描述符

数据库摘要

Ropotrectinib · CAS 1802220-02-5 · C18H18FN5O2. UNII 08O3FQ4UNP.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。