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Selumetinib

CAS 606143-52-6C17H15BrClFN4O3MW 457.7

Selumetinib (CAS No. 606143-52-6) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Organic Chemicals. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number606143-52-6
Molecular FormulaC17H15BrClFN4O3
Molecular Weight457.7
LogP3.6
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsOrganic Chemicals
CategoryOrganic Chemicals

Where it is used

Organic Chemicals

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Selumetinib?

The CAS number of Selumetinib is 606143-52-6.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Selumetinib?

Main applications include Organic Chemicals.

How do I buy Selumetinib or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Selumetinib · CAS 606143-52-6 · C17H15BrClFN4O3. UNII 6UH91I579U.

Identification

CAS Registry Number606143-52-6
PubChem CID10127622
Molecular formulaC17H15BrClFN4O3
IUPAC name6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
UNII (FDA)6UH91I579U

Computed Descriptors

Molecular Weight457.7
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass456.00001
Monoisotopic Mass456.00001
Topological Polar Surface Area88.4
Heavy Atom Count27
Formal Charge0

GHS Hazard Classification

Reported hazard statementsH302 (40%), H317 (80%), H318 (60%), H361 (80%), H373 (80%), H411 (60%), H413 (20%)

H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]

H317 (80%): May cause an allergic skin reaction [Warning Sensitization, Skin]

Documented Uses

  • Selumetinib is indicated for the treatment of neurofibromatosis type 1 (NF1) in adult and pediatric patients one year of age and older who have symptomatic, inoperable plexiform neurofibromas (PN).
  • Selumetinib is an oral, small molecule inhibitor of the mitogen activated protein kinase 1 and 2 (MEK1/2) that is used to treat symptomatic, refractory fibromas in neurofibromatosis type 1. Selumetinib is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury.
  • Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Tyrosine Kinase Inhibitors; Signal Transduction Inhibitors; MEK Inhibitors
  • Genetic Disorder Agents, Antineoplastic Agents
  • Take on an empty stomach. Avoid consuming food 2 hours before and 1 hour after each dose.
  • Established Pharmacologic Class [EPC] - Kinase Inhibitor

Synonyms

Selumetinib; 606143-52-6; AZD6244; ARRY-142886; 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE; AZD 6244; AZD-6244; ARRY-886; selumetinibum; DTXSID3048944; 6UH91I579U; ARRY142886; DTXCID0028870; CHEBI:90227; 1H-Benzimidazole-6-carboxamide, 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-; 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-

Frequently Asked Questions

What are the CAS number and molecular formula of Selumetinib?

CAS 606143-52-6; molecular formula C17H15BrClFN4O3; molecular weight — g/mol.

What other names is Selumetinib known by?

Selumetinib, 606143-52-6, AZD6244, ARRY-142886, 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE, AZD 6244.

Is Selumetinib classified as hazardous?

Hazard statements reported: H302, H317, H318, H361, H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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