磺培南依扎罗西

Description

Sulopenem Etzadroxil · CAS 1000296-70-7 · C19H27NO7S3. UNII 492M3I304T.

Identification

CAS Registry Number	1000296-70-7
PubChem CID	23642298
Molecular formula	C19H27NO7S3
IUPAC name	2-ethylbutanoyloxymethyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(1R,3S)-1-oxothiolan-3-yl]sulfanyl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
UNII (FDA)	492M3I304T

Computed Descriptors

Molecular Weight	477.6
XLogP3	2.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	11
Exact Mass	477.09496572
Monoisotopic Mass	477.09496572
Topological Polar Surface Area	180
Heavy Atom Count	30
Formal Charge	0

Documented Uses

• Sulopenem etzadroxil is indicated in combination with [probenecid] for the treatment of uncomplicated urinary tract infections caused by _Escherichia coli_, _Klebsiella pneumoniae_, or _Proteus mirabilis_ in adult women who have limited or no alternative oral antibacterial treatment options.
• Take with food. The absorption of sulopenem is improved when administered with a meal.
• Following rapid conversion into the active moiety, sulopenem bioavailability is approximately 40% in the fasted state, increasing to 64% when administered with a meal.
• Following a single oral dose of radiolabeled sulopenem etzadroxil in healthy adult subjects, 44.3% of radioactive product was recovered in the feces (26.9% as unchanged sulopenem) and 40.8% was recovered in the urine (3.1% as unchanged sulopenem).
• In the fasted state, the apparent volume of distribution of sulopenem is 134 liters. When administered with a high-fat meal, the apparent volume of distribution is 92.09 liters.
• In the fasted state, the apparent clearance of sulopenem is 77.6 L/h. When administered with a high-fat meal, the apparent clearance is 50.55 L/h.

Synonyms

SULOPENEM ETZADROXIL; 1000296-70-7; Sulopenem etzadroxil (USAN); Sulopenem etzadroxil [USAN]; 492M3I304T; PF-03709270; PF03709270; UNII-492M3I304T; RefChem:186740; PF 03709270; PF 03709270 (ulopenem etzadroxil); sulopenem-etzadroxil; SCHEMBL3412832; Sulopenem etzadroxil [WHO-DD]; DTXSID80635293; NBPVNGWRLGHULH-CSOWVJSESA-N

Frequently Asked Questions

What are the CAS number and molecular formula of Sulopenem Etzadroxil?

CAS 1000296-70-7; molecular formula C19H27NO7S3; molecular weight — g/mol.

What other names is Sulopenem Etzadroxil known by?

SULOPENEM ETZADROXIL, 1000296-70-7, Sulopenem etzadroxil (USAN), Sulopenem etzadroxil [USAN], 492M3I304T, PF-03709270.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.