塞黑诺肽

Description

Setmelanotide · CAS 920014-72-8 · C49H68N18O9S2. UNII N7T15V1FUY.

Identification

CAS Registry Number	920014-72-8
PubChem CID	11993702
Molecular formula	C49H68N18O9S2
IUPAC name	(4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[3-(diaminomethylideneamino)propyl]-16-(1H-imidazol-5-ylmethyl)-7-(1H-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxamide
UNII (FDA)	N7T15V1FUY

Computed Descriptors

Molecular Weight	1117.3
XLogP3	-2.5
Hydrogen Bond Donor Count	15
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	18
Exact Mass	1116.48580817
Monoisotopic Mass	1116.48580817
Topological Polar Surface Area	500
Heavy Atom Count	78
Formal Charge	0

Documented Uses

• Setmelanotide is the first available anorexigenic agent, a melanocortin-4 receptor (MC4R) agonist for treating obesity caused by a rare genetic disorder. Setmelanotide was approved by the Food and Drug Administration (FDA) on November 25, 2020, for the indication of chronic weight management in adults and pediatrics six years of age and older due to the deficiency of proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency.
• Setmelanotide is a melanocortin 4 receptor agonist that is used for chronic weight management for adults and children with rare genetic forms obesity due to gene defects in the melanocortin pathway. Setmelanotide therapy has not been associated serum aminotransferase or bilirubin elevations or to instances of clinically apparent liver injury.
• Breast Feeding; Lactation; Milk, Human; Hypoglycemic Agents; Incretins; Glucagon-Like Peptide-1 Agonists; GLP-1 Agonists
• Established Pharmacologic Class [EPC] - Melanocortin 4 Receptor Agonist
• Mechanisms of Action [MoA] - Melanocortin 4 Receptor Agonists
• Setmelanotide is a Melanocortin 4 Receptor Agonist. The mechanism of action of setmelanotide is as a Melanocortin 4 Receptor Agonist.

Synonyms

Setmelanotide; 920014-72-8; RM-493; BIM-22493; Setmelanotida; N7T15V1FUY; Setmelanotidum; DTXSID501032320; RefChem:58308; DTXCID101517326; Setmelanotide (RM-493); UNII-N7T15V1FUY; Setmelanotide [USAN:INN]; Setmelanotide [MI]; Setmelanotide [USAN]; SETMELANOTIDE [INN]

Frequently Asked Questions

What are the CAS number and molecular formula of Setmelanotide?

CAS 920014-72-8; molecular formula C49H68N18O9S2; molecular weight — g/mol.

What other names is Setmelanotide known by?

Setmelanotide, 920014-72-8, RM-493, BIM-22493, Setmelanotida, N7T15V1FUY.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.