塞莫斯汀

塞莫斯汀（CAS 13909-09-6）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea is a light yellow powder. (NTP, 1992)
• Crystals
• less than 1 mg/mL at 64 °F (NTP, 1992)
• Absolute Ethanol 100.00 (mg/mL)
• It is stable under normal conditions but should be protected from moisture.
• Bulk: A sample stored at room temperature for 30 days showed 4% decomposition (UV). Solution: A refrigerated solution in 10% EtOH decomposed 2% in 6 hours while a solution at room temperature showed 25% decomposition in 6 hours (UV). Solutions in methanol were also found to be unstable by UV analysis.

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• An antineoplastic agent which functions as an alkylating agent.
• Withdrawn as Investigational New Drug Application
• A methylated derivative of carmustine with antineoplastic activity.
• /EXPERIMENTAL THERAPY:/ Methyl-CCNU is an investigational drug used in chemotherapy to treat several types of cancers, including some brain cancers ... It also has been used to treat cancers of the lung and digestive tract.
• Dose-related nephrotoxicity subsequent to administration of certain chloroethylnitrosourea compounds (carmustine, semustine and streptozocin) is commonly heralded by increased serum creatinine levels, uremia and proteinuria .....
• A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA,

它在各数据库里的别名

semustine; 13909-09-6; Methyl-CCNU; 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; Semustina; MeCCNU; METHYL CCNU; N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea; Semustinum; ICIG 1110; methyl lomustine; Lomustine, methyl; NSC 95441; Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-; NCI-C04955; DTXSID8031603

计算机算出的分子描述符

数据库摘要

semustine · CAS 13909-09-6 · C10H18ClN3O2. UNII 2281H4FBL9. 熔点: 147 °F (NTP, 1992); 熔点: 64 °C (decomposes); 溶解度: Water 0.09 (mg/mL).

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。