泰乐菌素

Description

tylosin · CAS 1401-69-0 · C46H77NO17. UNII YEF4JXN031. Melting Point: 128-132 °C; Solubility: In water, 5 mg/mL at 25 °C; LogP: log Kow = 1.63.

Identification

CAS Registry Number	1401-69-0
PubChem CID	5280440
Molecular formula	C46H77NO17
UNII (FDA)	YEF4JXN031

Computed Descriptors

Molecular Weight	916.1
XLogP3	1
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	13
Exact Mass	915.51914999
Monoisotopic Mass	915.51914999
Topological Polar Surface Area	239
Heavy Atom Count	64
Formal Charge	0

Physical & Chemical Properties

Melting Point	128-132 °C
Solubility	In water, 5 mg/mL at 25 °C
LogP	log Kow = 1.63
Dissociation Constants	7.73
Dissociation Constants	pKa = 7.73
Collision Cross Section	304.23 Ų [M-H]-
Collision Cross Section	319.79 Ų [M+H]+

Physical description & handling notes

• Solid; [Merck Index] White to buff-colored powder with a mild musty odor; [USP MSDS]
• Crystals from water
• Freely soluble in methanol. Soluble in lower alcohols, esters and ketones, chloroform, dilute mineral acids, amyl acetate, chlorinated hydrocarbons, benzene, and ether.
• Stable under recommended storage conditions.
• Specific optical rotation: -46 deg at 25 °C/D (c = 2 cm methanol)
• When heated to decomposition it emits toxic fumes of /nitrogen oxide/.

Regulatory Status

Regulatory & Food Contact	ANTIMICROBIAL_AGENT: Veterinary Drug JECFA ADI: 0-0.03 mg/kg bw TRS 954- JECFA 70 TYLOSIN.pdf

GHS Hazard Classification

Reported hazard statements	H317 (98.7%), H319 (44%), H330 (37.3%), H334 (61.3%), H351 (37.3%), H373 (37.3%), H400 (89.3%), H410 (41.3%)

Documented Uses

• Tylosin is a veterinary macrolide antibiotic. [Kanerva, p. 1844] A macrolide antibiotic from a Streptomycetes fradiae strain found in the soil in Thailand; [Merck Index]
• Farming (Feed Additives) [Category: Industry]
• Veterinary antimicrobial agent also used as prophylactics during surgery or at generally lower levels of administration to promote an animal's ability to withstand pathogenic challenge when under stress.
• Used by injection or oral administration to treat Mycoplasma and gram-positive bacterial infections in poultry, swine, and other livestock.
• FDA regulated feed additive for chicken and livestock for growth rates and efficiency of gain
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Synonyms

Tylosin; Tylosin A; Tylosine; 1401-69-0; Tilosina; Tylocine; Tylan; Tylosinum; Fradizine; Vubityl 200; YEF4JXN031; DTXSID3043996; CHEBI:17658; BiloVet; Tylosin Base; Tartrate, Tylosin

Frequently Asked Questions

What are the CAS number and molecular formula of tylosin?

CAS 1401-69-0; molecular formula C46H77NO17; molecular weight — g/mol.

What other names is tylosin known by?

Tylosin, Tylosin A, Tylosine, 1401-69-0, Tilosina, Tylocine.

What is the regulatory status of tylosin?

Documented regulatory listings: ANTIMICROBIAL_AGENT: Veterinary Drug; JECFA ADI: 0-0.03 mg/kg bw; TRS 954- JECFA 70.

Is tylosin classified as hazardous?

Hazard statements reported: H317, H319, H330, H334, H351.

What are the key physical properties of tylosin?

Melting Point: 128-132 °C; Solubility: In water, 5 mg/mL at 25 °C; LogP: log Kow = 1.63; Dissociation Constants: 7.73.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.