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Description

Topotecan HCL · CAS 119413-54-6 · C23H24ClN3O5. UNII 956S425ZCY.

Identification

CAS Registry Number	119413-54-6
PubChem CID	60699
Molecular formula	C23H24ClN3O5
IUPAC name	(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride
UNII (FDA)	956S425ZCY

Computed Descriptors

Molecular Weight	457.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	457.1404486
Monoisotopic Mass	457.1404486
Topological Polar Surface Area	103
Heavy Atom Count	32
Formal Charge	0
Complexity	867

Physical description & handling notes

• 211.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H300 (37.5%), H301 (12.5%), H302 (12.5%), H315 (12.5%), H319 (12.5%), H335 (12.5%), H340 (87.5%), H350 (50%)

Documented Uses

• Breast Feeding; Lactation; Antineoplastic Agents; Topoisomerase I Inhibitors
• Hycamtin (Topotecan Hydrochloride)
• Topotecan hydrochloride is approved to be used alone or with other drugs to treat:
• • Cervical cancer that has spread to other parts of the body, has come back, or cannot be cured with other therapy. It is used with cisplatin.
• • Ovarian cancer that has spread to other parts of the body. It is used alone in patients whose cancer got worse during or after other chemotherapy.
• • Small cell lung cancer that is platinum sensitive. It is used alone in patients whose cancer got worse after first-line chemotherapy.

Synonyms

TOPOTECAN HYDROCHLORIDE; 119413-54-6; Topotecan Hcl; Nogitecan hydrochloride; Evotopin; Topotecan teva; Topotecan Actavis; Topotecan Hospira; SK&F S-104864-A; potactasol; NSC-759263; DTXSID1045952; SK&F-S-104864-A; Topotecan (as hydrochloride); 956S425ZCY; Hydrochloride, Nogitecan

Frequently Asked Questions

What are the CAS number and molecular formula of Topotecan HCL?

CAS 119413-54-6; molecular formula C23H24ClN3O5; molecular weight — g/mol.

What other names is Topotecan HCL known by?

TOPOTECAN HYDROCHLORIDE, 119413-54-6, Topotecan Hcl, Nogitecan hydrochloride, Evotopin, Topotecan teva.

Is Topotecan HCL classified as hazardous?

Hazard statements reported: H300, H301, H302, H315, H319.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.