二十六烷肽

Description

Tetracosactide · CAS 16960-16-0 · C136H210N40O31S. UNII 72YY86EA29.

Identification

CAS Registry Number	16960-16-0
PubChem CID	16129617
Molecular formula	C136H210N40O31S
UNII (FDA)	72YY86EA29

Computed Descriptors

Molecular Weight	2933.4
XLogP3	-7.9
Hydrogen Bond Donor Count	42
Hydrogen Bond Acceptor Count	41
Rotatable Bond Count	96
Exact Mass	2932.5839961
Monoisotopic Mass	2931.5806412
Topological Polar Surface Area	1180
Heavy Atom Count	208
Formal Charge	0

Physical description & handling notes

• Specific optical rotation: -88 +/- 2 deg at 22 °C/D (c = 0.511 in 1% acetic acid). UV max (0.1 NaOH): 283, 289 nm (epsilon 8550, 8810) /Cosyntropin hexacetate/
• Parenteral: for injection 0.25 mg Cortrosyn (with mannitol) (Organon).
• IM injection: 1 mg/mL, 1 mL ampoules; containers of 1, Synacthen Depot (Novartis Pharmaceuticals Australia Pty Ltd)

GHS Hazard Classification

Reported hazard statements	H317 (100%), H332 (100%), H334 (100%)

Documented Uses

• THERAPEUTIC CATEGORY: Diagnostic aid (adrenal function)
• THERAPEUTIC CATEGORY (VET): Diagnostic aid (adrenal function)
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Synthetic polypeptide corresponding to the first 24 amino acids of ACTH
• For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
• Investigationally, long-acting IM depot cosyntropin preparations have been used as an aid in the diagnosis of adrenocortical insufficiency and, in patients with normal adrenocortical function, in the long-term management of chronic inflammatory and degenerative disorders that are responsive to glucocorticoids. /NOT included in US product label/

Synonyms

Tetracosactide; COSYNTROPIN; Tetracosapeptide; Cortrosyn; Tetracosactid; Actholain; Synacthen; 16960-16-0; Tetracosactrin; Tetracosactida; Synthetic ACTH; Tetracosactide hexacetate; 1-24-Corticotropin; CHEBI:3901; ((2S,3R,4S)-2,3,4,5-tetrahydroxypentyl) dihydrogen phosphate; [(2S,3R,4S)-2,3,4,5-tetrahydroxypentyl] dihydrogen phosphate

Frequently Asked Questions

What are the CAS number and molecular formula of Tetracosactide?

CAS 16960-16-0; molecular formula C136H210N40O31S; molecular weight — g/mol.

What other names is Tetracosactide known by?

Tetracosactide, COSYNTROPIN, Tetracosapeptide, Cortrosyn, Tetracosactid, Actholain.

Is Tetracosactide classified as hazardous?

Hazard statements reported: H317, H332, H334.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.