曲匹地尔

Description

trapidil · CAS 15421-84-8 · C10H15N5. UNII EYG5Y6355E. European Pharmacopoeia monograph. Solubility: 41; LogP: 1.42.

Identification

CAS Registry Number	15421-84-8
PubChem CID	5531
Molecular formula	C10H15N5
IUPAC name	N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
UNII (FDA)	EYG5Y6355E
Pharmacopoeial monograph	European Pharmacopoeia monograph

Computed Descriptors

Molecular Weight	205.26
XLogP3	1.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	205.13274550
Monoisotopic Mass	205.13274550
Topological Polar Surface Area	46.3
Heavy Atom Count	15
Formal Charge	0

Physical & Chemical Properties

Solubility	41
LogP	1.42

Physical description & handling notes

• >30.8 [ug/mL] (The mean of the results at pH 7.4)
• Trapidil exerts vasodilatory and antiplatelet effects. It also inhibits the activity of platelet derived growth factor (PDGF).

GHS Hazard Classification

Reported hazard statements	H315 (97.4%), H319 (97.4%), H335 (97.4%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >1000
• Consumption (g per capita; approx.) in Germany (2009): 0.0122
• Used in the treatment of chronic stable angina.
• Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
• Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
• Drugs used to cause dilation of the blood vessels.

Synonyms

trapidil; 15421-84-8; Rocornal; Trapymin; N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; AR 12008; Trapidilum; DTXSID0045416; AR-12008; (1,2,4)Triazolo(1,5-a)pyrimidin-7-amine, N,N-diethyl-5-methyl-; EYG5Y6355E; DTXCID8025416; [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, N,N-diethyl-5-methyl-; N,N-diethyl-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidin-7-amine; RefChem:389337; C01DX11

Frequently Asked Questions

What are the CAS number and molecular formula of trapidil?

CAS 15421-84-8; molecular formula C10H15N5; molecular weight — g/mol.

What other names is trapidil known by?

trapidil, 15421-84-8, Rocornal, Trapymin, N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, AR 12008.

Is trapidil classified as hazardous?

Hazard statements reported: H315, H319, H335.

Does trapidil have a pharmacopoeial monograph?

Yes — a monograph exists in the European Pharmacopoeia (Ph. Eur.).

What are the key physical properties of trapidil?

Solubility: 41; LogP: 1.42.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.