替比法尼

Description

Tipifarnib · CAS 192185-72-1 · C27H22Cl2N4O. UNII MAT637500A.

Identification

CAS Registry Number	192185-72-1
PubChem CID	159324
Molecular formula	C27H22Cl2N4O
IUPAC name	6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
UNII (FDA)	MAT637500A

Computed Descriptors

Molecular Weight	489.4
XLogP3	4.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	488.1170667
Monoisotopic Mass	488.1170667
Topological Polar Surface Area	64.2
Heavy Atom Count	34
Formal Charge	0

Physical description & handling notes

• R115777, a nonpeptidomimetic farnesyl transferase inhibitor, suppresses the growth of human pancreatic adenocarcinoma cell lines. This growth inhibition is associated with modulation in the phosphorylation levels of signal transducers and activators of transcription 3 (STAT3) and extracellular signal-regulated kinases (ERK).

GHS Hazard Classification

Reported hazard statements	H302 (33.3%), H315 (100%), H319 (100%), H335 (66.7%), H373 (33.3%)

Documented Uses

• Investigated for use/treatment in colorectal cancer, leukemia (myeloid), pancreatic cancer, and solid tumors.
• Substances that inhibit or prevent the proliferation of NEOPLASMS.

Synonyms

Tipifarnib; 192185-72-1; Zarnestra; R-115777; (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; tipifarnibum; R-11577; NSC-702818; 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one; MAT637500A; DTXSID5041140; CHEBI:141969; NSC702818; (R)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; 6-((R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2-one; RefChem:898221

Frequently Asked Questions

What are the CAS number and molecular formula of Tipifarnib?

CAS 192185-72-1; molecular formula C27H22Cl2N4O; molecular weight — g/mol.

What other names is Tipifarnib known by?

Tipifarnib, 192185-72-1, Zarnestra, R-115777, (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone, tipifarnibum.

Is Tipifarnib classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.