盐酸替沃扎尼

Description

Tivozanib hydrochloride · CAS 682745-41-1 · C22H22Cl2N4O6. UNII 8A9H4VK35Z.

Identification

CAS Registry Number	682745-41-1
PubChem CID	11547978
Molecular formula	C22H22Cl2N4O6
IUPAC name	1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea;hydrate;hydrochloride
UNII (FDA)	8A9H4VK35Z

Computed Descriptors

Molecular Weight	509.3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	508.0916398
Monoisotopic Mass	508.0916398
Topological Polar Surface Area	109
Heavy Atom Count	34
Formal Charge	0
Complexity	631

Documented Uses

• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Tyrosine Kinase Inhibitors
• Fotivda (Tivozanib Hydrochloride)
• Tivozanib hydrochloride is approved to treat:
• • Renal cell carcinoma (a type of kidney cancer) that is advanced. It is used in adults whose disease has relapsed (come back) or is refractory (does not respond to treatment) after at least two other types of systemic therapy.
• Tivozanib hydrochloride is also being studied in the treatment of other types of cancer.

Synonyms

TIVOZANIB HYDROCHLORIDE; 682745-41-1; Tivozanib hydrochloride hydrate; Tivozanib HCl hydrate; Tivozanib hydrochloride monohydrate; UNII-8A9H4VK35Z; 8A9H4VK35Z; fotivda; Tivozanib monohydrochloride monohydrate; RefChem:58430; Tivozanib (hydrochloride hydrate); Tivozanib hydrochloride [USAN]; (TIVOZANIB HYDROCHLORIDE HYDRATE; Tivozanib hydrochloride (USAN); 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea;hydrate;hydrochloride; ASP-4130

Frequently Asked Questions

What are the CAS number and molecular formula of Tivozanib hydrochloride?

CAS 682745-41-1; molecular formula C22H22Cl2N4O6; molecular weight — g/mol.

What other names is Tivozanib hydrochloride known by?

TIVOZANIB HYDROCHLORIDE, 682745-41-1, Tivozanib hydrochloride hydrate, Tivozanib HCl hydrate, Tivozanib hydrochloride monohydrate, UNII-8A9H4VK35Z.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.