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Description

Tazemetostat hydrobromide · CAS 1467052-75-0 · C34H44N4O4. UNII Q40W93WPE1. LogP: 2.82.

Identification

CAS Registry Number	1467052-75-0
PubChem CID	66558664
Molecular formula	C34H44N4O4
IUPAC name	N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide
UNII (FDA)	Q40W93WPE1

Computed Descriptors

Molecular Weight	572.7
XLogP3	4.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	572.33625590
Monoisotopic Mass	572.33625590
Topological Polar Surface Area	83.1
Heavy Atom Count	42
Formal Charge	0

Physical & Chemical Properties

LogP	2.82

Physical description & handling notes

• Tazemetostat is a methyltransferase inhibitor that prevents hyper-trimethylation of histones and inhibits cancer cell de-differentiation. The duration of action is long as it is given twice daily. Patients should be counselled regarding the risk of secondary malignancies and embryo-fetal toxicity.

Documented Uses

• Tazemetostat is a methyltransferase inhibitor and antineoplastic agent used in the therapy of advanced epithelioid sarcoma. Tazemetostat is associated with a moderate rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice.
• Established Pharmacologic Class [EPC] - Methyltransferase Inhibitor
• Mechanisms of Action [MoA] - Methyltransferase Inhibitors
• Mechanisms of Action [MoA] - Multidrug and Toxin Extrusion Transporter 1 Inhibitors
• Tazemetostat is a Methyltransferase Inhibitor. The mechanism of action of tazemetostat is as a Methyltransferase Inhibitor, and Multidrug and Toxin Extrusion Transporter 1 Inhibitor, and Multidrug and Toxin Extrusion Transporter 2 K Inhibitor.
• Methyltransferase Inhibitors [MoA]; Multidrug and Toxin Extrusion Transporter 1 Inhibitors [MoA]; Multidrug and Toxin Extrusion Transporter 2 K Inhibitors [MoA]; Methyltransferase Inhibitor [EPC]

Synonyms

Tazemetostat; 1403254-99-8; EPZ-6438; EPZ6438; E7438; Tazemetostatum; E-7438; Q40W93WPE1; DTXSID201025831; RefChem:56753; DTXCID601510082; EPZ 6438; Tazemetostat (EPZ-6438); Tazemetostat [INN]; MFCD24849415; Tazemetostat [USAN]

Frequently Asked Questions

What are the CAS number and molecular formula of Tazemetostat hydrobromide?

CAS 1467052-75-0; molecular formula C34H44N4O4; molecular weight — g/mol.

What other names is Tazemetostat hydrobromide known by?

Tazemetostat, 1403254-99-8, EPZ-6438, EPZ6438, E7438, Tazemetostatum.

What are the key physical properties of Tazemetostat hydrobromide?

LogP: 2.82.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.