维莫非尼

维莫非尼（CAS 1029872-54-5）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• White to off-white crystalline solid
• Practically insoluble in aqueous media
• Stable if stored as directed; avoid strong oxidizing agents
• Dangerous products of decomposition: thermal ecomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.
• Oral: Tablets, film-coated: 240 mg, Zelboraf (Genentech).

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Vemurafenib is a selective inhibitor of BRAF kinase that is used in the therapy of patients with metastatic and advanced malignant melanoma. Vemurafenib therapy is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe cases of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors;
• Vemurafenib is approved to treat patients whose cancer has a certain mutation in the BRAF gene, including:
• • Melanoma that cannot be removed by surgery or has spread to other parts of the body.
• Vemurafenib is also being studied in the treatment of other types of cancer.
• Vemurafenib is used for the treatment of unresectable or metastatic melanoma with BRAF V600E mutation. Vemurafenib is designated an orphan drug by the US Food and Drug Administration (FDA) for the treatment of this cancer. An FDA-approved diagnostic test (e.g., cobas 4800 BRAF V600 Mutation Test) is required to confirm the presence of the BRAF V600E mutation prior to initiation of therapy. /Included in US product label/

它在各数据库里的别名

Vemurafenib; 918504-65-1; Zelboraf; PLX-4032; PLX 4032; RG7204; RG 7204; RO 5185426; 207SMY3FQT; vemurafenibum; N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide; RG-7204; Ro 51-85426; RO-5185426; RO-51-85426; CHEBI:63637

计算机算出的分子描述符

数据库摘要

Vemurafenib · CAS 1029872-54-5 · C23H18ClF2N3O3S. UNII 207SMY3FQT. 熔点: 272°C; 溶解度: <1 mg/mL; LogP: 5.1.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。