凡德他尼

凡德他尼（CAS 443913-73-3）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• In water, 330 uM (pH 7.4); approx 650 uM (pH approx 6.5)
• Vandetanib solid is found to be stable to both thermal and hydrolytic degradation but a small degree of degradation is observed under stressed photolytic conditions. In solution, vandetanib is degraded under acidic, oxidative and light stress conditions but it is stable under basic conditions.
• Stable if stored as directed; avoid strong oxidizing agents
• Thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.
• Mean IC50 of approximately 2.1 μg/mL.
• Table: Vandetanib Preparations [Table#8178]

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Preparation: L. F. A. Hennequin et al., World Intellectual Property Organization patent 01032651; eidem, United States of America patent 7173038 (2001, 2007 both to AstraZeneca).
• Vandetanib is currently approved as an alternative to local therapies for both unresectable and disseminated disease. Because Vandetanib can prolong the Q-T interval, it is contraindicated for use in patients with serious cardiac complications such as congenital long QT syndrome and uncompensated heart failure.
• Vandetanib is a multi-kinase inhibitor that is used in the therapy of advanced or metastatic medullary thyroid cancer. Vandetanib therapy is commonly associated with transient elevations in serum aminotransferase during therapy, but has not been linked to cases of clinically apparent acute liver injury with jaundice.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors;
• Vandetanib is approved to treat:
• • Medullary thyroid cancer that cannot be removed by surgery and is locally advanced or has metastasized (spread to other parts of the body).

它在各数据库里的别名

Vandetanib; 443913-73-3; Zactima; ZD6474; Caprelsa; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; ZD-6474; ZD 6474; GNF-PF-2188; ZD-64; NSC-744325; NSC-760766; DTXSID1046681; YO460OQ37K; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine

计算机算出的分子描述符

数据库摘要

Vandetanib · CAS 443913-73-3 · C22H24BrFN4O2. UNII YO460OQ37K. 溶解度: 0.008; LogP: log Kow = 5.0.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。