缬更昔洛韦

Description

Valganciclovir · CAS 175865-60-8 · C14H22N6O5. UNII GCU97FKN3R. Solubility: 4.79e+00 g/L.

Identification

CAS Registry Number	175865-60-8
PubChem CID	135413535
Molecular formula	C14H22N6O5
IUPAC name	[2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-2-amino-3-methylbutanoate
UNII (FDA)	GCU97FKN3R

Computed Descriptors

Molecular Weight	354.36
XLogP3	-1.5
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	354.16516782
Monoisotopic Mass	354.16516782
Topological Polar Surface Area	167
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Solubility	4.79e+00 g/L

Physical description & handling notes

• Solid
• When heated to decomposition material emits toxic fumes of /nitrogen oxides/, ammonia, and hydrogen chloride.
• MW: 390.82. Crystals from water + isopropanol, undergoes phase change at 142 °C; decomposes at 175 °C /Valganciclovir hydrochloride/
• Table: Valganciclovir Hydrochloride Preparations [Table#8063]

Documented Uses

• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Preparation: J.J. Nestor et al., EP 694547; eidem, US 6083953 (1996, 2000 both to Hoffmann-La Roche)
• Valganciclovir is an antiviral medication used for the treatment of cytomegalovirus infections.
• Breast Feeding; Lactation; Anti-Infective Agents; Antiviral Agents
• (1) Oral - Liquid: 50 mg per mL powder for oral solution; (2) Oral - Solid - tablet: 450 mg

Synonyms

Valganciclovir; 175865-60-8; GCU97FKN3R; L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl ester; DTXSID8048288; CHEBI:63635; 2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate; L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester; valganciclovirum; 2-((2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy)-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate; RefChem:56199; ganciclovir L-valyl ester; Ganciclovir L valyl Ester; DTXCID3028263; J05AB14; L-Valine, 2-((2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl ester

Frequently Asked Questions

What are the CAS number and molecular formula of Valganciclovir?

CAS 175865-60-8; molecular formula C14H22N6O5; molecular weight — g/mol.

What other names is Valganciclovir known by?

Valganciclovir, 175865-60-8, GCU97FKN3R, L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl ester, DTXSID8048288, CHEBI:63635.

What are the key physical properties of Valganciclovir?

Solubility: 4.79e+00 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.