扎那米韦水合物

Description

ZANAMIVIR HYDRATE · CAS 139110-80-8 · C12H20N4O7. UNII L6O3XI777I. Melting Point: 256 °C; Solubility: In water, 18,000 mg/L at 25 °C; Solubility: 7.31e+00 g/L.

Identification

CAS Registry Number	139110-80-8
PubChem CID	60855
Molecular formula	C12H20N4O7
IUPAC name	(2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
UNII (FDA)	L6O3XI777I

Computed Descriptors

Molecular Weight	332.31
XLogP3	-3.2
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	332.13319899
Monoisotopic Mass	332.13319899
Topological Polar Surface Area	201
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Melting Point	256 °C
Solubility	In water, 18,000 mg/L at 25 °C
Solubility	7.31e+00 g/L
LogP	-3

Physical description & handling notes

• Solid
• White to off-white powder
• Specific optical rotation (0.9% in water): +40.9 deg at 20 °C/D
• Colorless crystals /Sesquihydrate/
• Zwitterionic at physiological pH.
• Oral Inhalation: Powder for inhalation (contained in Rotadisk foil pack): 5 mg per inhalation Relenza (with Diskhaler), (GlaxoSmithKline).

Regulatory Status

GHS notification summary	2.5% (1 / 40)

GHS Hazard Classification

GHS notification summary	2.5% (1 / 40)
Reported hazard statements	H302 (97.5%), H315 (97.5%), H319 (97.5%), H335 (97.5%)

Documented Uses

• Antiviral Agents; Enzyme Inhibitors
• L. M. von Itzstein et al., WO 91 16320; eidem, US patent 5360817 (1991, 1994 both to Biota)
• For the prevention and treatment of influenza A and B.
• Zanamivir is an inhibitor of the influenza neuraminidase enzyme and is given by inhalation as therapy and prophylaxis against influenza A and B. Zanamivir has not been associated with clinically apparent liver injury, at least when given by inhalation.
• Breast Feeding; Lactation; Antiviral Agents; Neuraminidase Inhibitors
• At this time, CDC recommends the use of oseltamivir or zanamivir for the treatment of infection with swine influenza (H1N1) viruses.

Synonyms

zanamivir; 139110-80-8; Relenza; GANA; 4-Guanidino-Neu5Ac2en; GG167; GG-167; GR-121167X; DTXSID0023749; GR 121167X; GANA (inhibitor); GG 167; 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid; L6O3XI777I; GR-121167; 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic acid

Frequently Asked Questions

What are the CAS number and molecular formula of ZANAMIVIR HYDRATE?

CAS 139110-80-8; molecular formula C12H20N4O7; molecular weight — g/mol.

What other names is ZANAMIVIR HYDRATE known by?

zanamivir, 139110-80-8, Relenza, GANA, 4-Guanidino-Neu5Ac2en, GG167.

Is ZANAMIVIR HYDRATE classified as hazardous?

2.5% of GHS notifications report no hazard classification (1 of 40).

What are the key physical properties of ZANAMIVIR HYDRATE?

Melting Point: 256 °C; Solubility: In water, 18,000 mg/L at 25 °C; Solubility: 7.31e+00 g/L; LogP: -3.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.