6α-甲基泼尼松龙

Description

6alpha-methylprednisolone · CAS 83-43-2 · C22H30O5. UNII X4W7ZR7023. Melting Point: 232.5; Melting Point: 228-237 °C; Melting Point: 232.5 °C.

Identification

CAS Registry Number	83-43-2
PubChem CID	6741
Molecular formula	C22H30O5
IUPAC name	(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
UNII (FDA)	X4W7ZR7023

Computed Descriptors

Molecular Weight	374.5
XLogP3	1.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	374.20932405
Monoisotopic Mass	374.20932405
Topological Polar Surface Area	94.8
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Melting Point	232.5
Melting Point	228-237 °C
Melting Point	232.5 °C
Solubility	120
Solubility	In water, 1.20X10+2 mg/L at 25 °C
Solubility	1.09e-01 g/L
LogP	1.525
LogP	1.5
LogP	2.12
Collision Cross Section	189.92 Ų [M+H-H2O]+

Physical description & handling notes

• Solid
• Crystals
• White to practically white crystalline powder
• Odorless
• MW 416.51, crystals, MP 205-208 °C, specific optical rotation: 101 deg at 20 °C (dioxane), uv max (95% ethanol): 243 nm (alpha m 14825), Sol in dioxane; sparingly sol in acetone, alcohol, chloroform, methanol; slightly sol in ether. Practically insol in water. /21-acetate/
• SOL IN WATER /METHYLPREDNISOLONE 21-SUCCINATE SODIUM SALT/

Regulatory Status

GHS notification summary	0.9% (1 / 110)

GHS Hazard Classification

GHS notification summary	0.9% (1 / 110)
Reported hazard statements	H302 (16.4%), H312 (15.5%), H360 (79.1%), H361 (18.2%), H372 (22.7%), H373 (57.3%)

Documented Uses

• Used to treat rheumatoid arthritis
• Used in dogs and cats as an anti-inflammatory agent. /Medrol Tablets/
• Used in dogs as an analgesic agent. /Cortoba Tablets/
• Treatment of inflammation and related disorders in cats and dogs; treatment of allergic and dermatologic disorders in cats and dogs; and as supportive therapy to antibacterial treatment of severe infections in cats and dogs. Treatment of inflammation and related disorders in horses. /Depo-Medrol Sterile Aqueous Suspension/
• For more Uses (Complete) data for METHYLPREDNISOLONE (9 total), please visit the HSDB record page.
• Use (kg) in Switzerland (2009): >25

Synonyms

methylprednisolone; 83-43-2; Medrate; Medrone; Urbason; 6alpha-Methylprednisolone; Metilbetasone; Promacortine; Metastab; Metrisone; Wyacort; Dopomedrol; Medesone; Noretona; Suprametil; Besonia

Frequently Asked Questions

What are the CAS number and molecular formula of 6alpha-methylprednisolone?

CAS 83-43-2; molecular formula C22H30O5; molecular weight — g/mol.

What other names is 6alpha-methylprednisolone known by?

methylprednisolone, 83-43-2, Medrate, Medrone, Urbason, 6alpha-Methylprednisolone.

Is 6alpha-methylprednisolone classified as hazardous?

0.9% of GHS notifications report no hazard classification (1 of 110).

What are the key physical properties of 6alpha-methylprednisolone?

Melting Point: 232.5; Melting Point: 228-237 °C; Melting Point: 232.5 °C; Solubility: 120.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.