17A-羟基孕酮己酸酯

Description

17A-hydroxyprogesterone hexanoate · CAS 630-56-8 · C27H40O4. UNII 276F2O42F5. Melting Point: 119-121.

Identification

CAS Registry Number	630-56-8
PubChem CID	169870
Molecular formula	C27H40O4
IUPAC name	[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] hexanoate
UNII (FDA)	276F2O42F5

Computed Descriptors

Molecular Weight	428.6
XLogP3	5.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Exact Mass	428.29265975
Monoisotopic Mass	428.29265975
Topological Polar Surface Area	60.4
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Melting Point	119-121

Physical description & handling notes

• 225.6 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID6043915]
• 212.9 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID6043915]
• No specific pharmacodynamic studies have been performed to assess hydroxyprogesterone caproate injections. However, the mechanism of action is likely related to increased interaction between progesterone and progesterone receptors.

GHS Hazard Classification

Reported hazard statements	H360 (93.2%)

Documented Uses

• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Hydroxyprogesterone caproate was previously indicated in the US for the prevention of spontaneous preterm births in singleton pregnancies in women with a history of spontaneous preterm birth. This indication was revoked by the FDA in April 2023. Hydroxyprogesterone caproate remains indicated in other jurisdictions for the management of primary and secondary amenorrhea, corpus luteum insufficiency, and for the prevention of preterm birth.
• Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.
• Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.
• Progesterone Congeners [CS]; Progestin [EPC]
• Absorption of 17-hydroxyprogesteron caproate is slow, occurring over a long period of time.

Synonyms

HYDROXYPROGESTERONE CAPROATE; 630-56-8; Delalutin; Primolut Depot; Hydroxyprogesterone hexanoate; Hormofort; Syngynon; Proluton Depot; Depo-Proluton; Teralutil; Hylutin; Makena; Pharlon; 17alpha-Hydroxyprogesterone caproate; Procyte depo; NSC-17592

Frequently Asked Questions

What are the CAS number and molecular formula of 17A-hydroxyprogesterone hexanoate?

CAS 630-56-8; molecular formula C27H40O4; molecular weight — g/mol.

What other names is 17A-hydroxyprogesterone hexanoate known by?

HYDROXYPROGESTERONE CAPROATE, 630-56-8, Delalutin, Primolut Depot, Hydroxyprogesterone hexanoate, Hormofort.

Is 17A-hydroxyprogesterone hexanoate classified as hazardous?

Hazard statements reported: H360.

What are the key physical properties of 17A-hydroxyprogesterone hexanoate?

Melting Point: 119-121.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.