2-(1-哌嗪基)嘧啶

Description

2-(1-Piperazinyl)pyrimidine · CAS 20980-22-7 · C8H12N4. UNII H3B5B38F56. LogP: 0.49; Dissociation Constants: 8.9.

Identification

CAS Registry Number	20980-22-7
PubChem CID	88747
Molecular formula	C8H12N4
IUPAC name	2-piperazin-1-ylpyrimidine
UNII (FDA)	H3B5B38F56

Computed Descriptors

Molecular Weight	164.21
XLogP3	0
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	164.106196400
Monoisotopic Mass	164.106196400
Topological Polar Surface Area	41.1
Heavy Atom Count	12
Formal Charge	0

Physical & Chemical Properties

LogP	0.49
Dissociation Constants	8.9

GHS Hazard Classification

Reported hazard statements	H314 (31.3%), H315 (68.7%), H319 (65.7%), H335 (65.7%)

Documented Uses

• Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
• Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
• 2-(1-piperazinyl)pyrimidine has known human metabolites that include 2-(Piperazin-1-yl)pyrimidin-5-ol.
• 2-(1-piperazinyl)pyrimidine is a known human metabolite of gepirone.

Synonyms

20980-22-7; 2-(Piperazin-1-yl)pyrimidine; 1-(2-Pyrimidinyl)piperazine; Pyrimidine, 2-(1-piperazinyl)-; 1-pyrimidinylpiperazine; H3B5B38F56; DTXSID00864967; MJ-13653; RefChem:422655; DTXCID80208042; 244-135-5; 2-(1-Piperazinyl)pyrimidine; 1-(2-Pyrimidyl)piperazine; 2-piperazin-1-ylpyrimidine; Buspirone EP Impurity A; 2-Piperazino-pyrimidine

Frequently Asked Questions

What are the CAS number and molecular formula of 2-(1-Piperazinyl)pyrimidine?

CAS 20980-22-7; molecular formula C8H12N4; molecular weight — g/mol.

What other names is 2-(1-Piperazinyl)pyrimidine known by?

20980-22-7, 2-(Piperazin-1-yl)pyrimidine, 1-(2-Pyrimidinyl)piperazine, Pyrimidine, 2-(1-piperazinyl)-, 1-pyrimidinylpiperazine, H3B5B38F56.

Is 2-(1-Piperazinyl)pyrimidine classified as hazardous?

Hazard statements reported: H314, H315, H319, H335.

What are the key physical properties of 2-(1-Piperazinyl)pyrimidine?

LogP: 0.49; Dissociation Constants: 8.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.