2-(1-萘甲基)-2-咪唑啉盐酸盐

Description

2-(1-Naphthylmethyl)-2-imidazoline hydrochloride · CAS 550-99-2 · C14H14N2.ClH. UNII MZ1131787D. Melting Point: 255-260 °C; Solubility: In water, 4.0X10+5 mg/L at 25 °C; Dissociation Constants: pKa = 10.35 (25 °C); pKa = 10.13 (35 °C); pKa = 9.92 (45 °C).

Identification

CAS Registry Number	550-99-2
PubChem CID	11079
Molecular formula	C14H14N2.ClH
IUPAC name	2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride
UNII (FDA)	MZ1131787D

Computed Descriptors

Molecular Weight	246.73
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	246.0923762
Monoisotopic Mass	246.0923762
Topological Polar Surface Area	24.4
Heavy Atom Count	17
Formal Charge	0
Complexity	272

Physical & Chemical Properties

Melting Point	255-260 °C
Solubility	In water, 4.0X10+5 mg/L at 25 °C
Dissociation Constants	pKa = 10.35 (25 °C); pKa = 10.13 (35 °C); pKa = 9.92 (45 °C)
Other Experimental Properties	DECOMP @ 253-258 °C

Physical description & handling notes

• WHITE CRYSTALLINE POWDER
• ODORLESS
• Bitter
• Soluble in ethanol; slightly soluble in chlorform; insoluble in benzene and ether
• >37 [ug/mL] (The mean of the results at pH 7.4)
• NAPHAZOLINE HYDROCHLORIDE WAS STABLE FOR 2 MO @ 5 & 15 °C.

GHS Hazard Classification

Reported hazard statements	H300 (86.3%)

Documented Uses

• THERAP CAT: Adrenergic (vasoconstrictor); decongestant /Naphazoline/
• The imidazoline derivative naphazoline, an alpha-2-adrenergic agonist, is used as non-prescription eye and nasal preparation because of its vasoconstrictive and decongestive properties.
• IN ALMOST QUANTITATIVE YIELDS BY HEATING 1-NAPHTHYLACETONITRILE WITH ETHYLENEDIAMINE MONOHYDROCHLORIDE @ 175 TO 200 °C FOR 1 HR. AMMONIA IS...BY-PRODUCT.
• Adrenergic alpha-Agonists; Nasal Decongestants
• Naphazoline is applied topically to the conjunctiva to temporarily relieve congestion, itching, and minor irritation. Ocular decongestants are ineffective in the treatment of delayed hypersensitivity reactions such as contact dermatoconjunctivitis. The vasoconstrictor effects of naphazoline may be used during some ocular diagnostic procedures, but some clinicians prefer phenylephrine to naphazoline for this use.
• Ophthalmic solutions containing naphazoline in combination with antihistamines such as antazoline phosphate or pheniramine maleate and/or astringents such as zinc sulfate are commercially available. In the concentrations usually employed, zinc sulfate is a relatively ineffective antiseptic and may promote vasodilation.

Synonyms

NAPHAZOLINE HYDROCHLORIDE; 550-99-2; NAPHAZOLINE HCL; Albalon; Vasocon; Opcon; Rhinantin; Rhinoperd; Stricylon; Niazol; Naphcon forte; Privine hydrochloride; Naphazoline chloride; Coldan; Sanorin; Prizole hydrochloride

Frequently Asked Questions

What are the CAS number and molecular formula of 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride?

CAS 550-99-2; molecular formula C14H14N2.ClH; molecular weight — g/mol.

What other names is 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride known by?

NAPHAZOLINE HYDROCHLORIDE, 550-99-2, NAPHAZOLINE HCL, Albalon, Vasocon, Opcon.

Is 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride classified as hazardous?

Hazard statements reported: H300.

What are the key physical properties of 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride?

Melting Point: 255-260 °C; Solubility: In water, 4.0X10+5 mg/L at 25 °C; Dissociation Constants: pKa = 10.35 (25 °C); pKa = 10.13 (35 °C); pKa = 9.92 (45 °C); Other Experimental Properties: DECOMP @ 253-258 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.