4-(正丁基氨基)苯甲酸2-(二甲氨基)乙酯

Description

2-(Dimethylamino)ethyl 4-(n-butylamino)benzoate · CAS 94-24-6 · C15H24N2O2. UNII 0619F35CGV. LogP: 3.46; Dissociation Constants: 8.49; Dissociation Constants: 8.5.

Identification

CAS Registry Number	94-24-6
PubChem CID	5411
Molecular formula	C15H24N2O2
IUPAC name	2-(dimethylamino)ethyl 4-(butylamino)benzoate
UNII (FDA)	0619F35CGV

Computed Descriptors

Molecular Weight	264.36
XLogP3	3.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	264.183778013
Monoisotopic Mass	264.183778013
Topological Polar Surface Area	41.6
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

LogP	3.46
Dissociation Constants	8.49
Dissociation Constants	8.5
Dissociation Constants	8.6

Physical description & handling notes

• 158.41 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 164.78 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 170.85 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 173.1 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 173.5 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated]

GHS Hazard Classification

Reported hazard statements	H301 (97.7%), H317 (93%), H351 (93%)

Documented Uses

• Used as a local anesthetic by dentists and other surgeons; [Kanerva, p. 1748]
• Use (kg; approx.) in Germany (2009): >50
• Consumption (g per capita; approx.) in Germany (2009): 0.000611
• Ophthalmic tetracaine is indicated for the for procedures requiring a rapid and short- acting topical ophthalmic anesthetic. The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access. The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.
• Tetracaine is a local anesthetic of the amino-ester class. The World Health Organization (WHO) lists tetracaine as an essential drug, and it is relatively inexpensive compared to other local anesthetic agents.
• Breast Feeding; Lactation; Milk, Human; Anesthetics, Local

Synonyms

tetracaine; 94-24-6; Amethocaine; 2-(Dimethylamino)ethyl 4-(butylamino)benzoate; Laudocaine; Metraspray; Pontocaine; Anetain; Dicaine; Uromucaesthin; Contralgin; Fissucain; Intercain; Medicaine; Meethobalm; Mucaesthin

Frequently Asked Questions

What are the CAS number and molecular formula of 2-(Dimethylamino)ethyl 4-(n-butylamino)benzoate?

CAS 94-24-6; molecular formula C15H24N2O2; molecular weight — g/mol.

What other names is 2-(Dimethylamino)ethyl 4-(n-butylamino)benzoate known by?

tetracaine, 94-24-6, Amethocaine, 2-(Dimethylamino)ethyl 4-(butylamino)benzoate, Laudocaine, Metraspray.

Is 2-(Dimethylamino)ethyl 4-(n-butylamino)benzoate classified as hazardous?

Hazard statements reported: H301, H317, H351.

What are the key physical properties of 2-(Dimethylamino)ethyl 4-(n-butylamino)benzoate?

LogP: 3.46; Dissociation Constants: 8.49; Dissociation Constants: 8.5; Dissociation Constants: 8.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.