2(S)-[2-氧代-4(R)-丙基吡咯烷-1-基]丁酰胺

Description

2(S)-[2-Oxo-4(R)-propylpyrrolidin-1-yl]butyramide · CAS 357336-20-0 · C11H20N2O2. UNII U863JGG2IA. European Pharmacopoeia monograph. LogP: 1.0.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Brivaracetam binds SV2A with high affinity. SV2A is known to play a role in epileptogenesis through modulation of synaptic GABA release. It is thought that brivaracetam exerts its anti-epileptogenic effects through its binding to SV2A. Brivaracetam is also known to inhibit Na+ channels which may also contribute to its anti-epileptogenic action.

GHS Hazard Classification

Documented Uses

• Used as adjunctive therapy for partial-onset seizures in patients 16 years of age or older.
• Brivaracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Brivaracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and is suspected of causing rare cases of clinically apparent drug induced liver disease.
• Breast Feeding; Lactation; Milk, Human; Anticonvulsants
• Brivaracetam (Class: Other Substances, Added Date: 06-2020)
• Schedule V - Substances in the DEA Schedule V have a low potential for abuse relative to substances listed in Schedule IV and consist primarily of preparations containing limited quantities of certain narcotics.
• Avoid alcohol. Taking Brivaracetam with alcohol may increase alcohol's effects on attention, memory, and psychomotor functioning.

Synonyms

Brivaracetam; 357336-20-0; Briviact; UCB 34714; UCB-34714; UCB34714; (2s)-2-[(4r)-2-oxo-4-propylpyrrolidin-1-yl]butanamide; U863JGG2IA; 1-Pyrrolidineacetamide, alpha-ethyl-2-oxo-4-propyl-, (alphaS,4R)-; CHEBI:133013; DTXSID00905081; (2S)-2-((4R)-2-Oxo-4-propylpyrrolidin-1-yl)butanamide; brivaracetamum; RefChem:57048; N03AX23; DTXCID601334183

Frequently Asked Questions

What are the CAS number and molecular formula of 2(S)-[2-Oxo-4(R)-propylpyrrolidin-1-yl]butyramide?

CAS 357336-20-0; molecular formula C11H20N2O2; molecular weight — g/mol.

What other names is 2(S)-[2-Oxo-4(R)-propylpyrrolidin-1-yl]butyramide known by?

Brivaracetam, 357336-20-0, Briviact, UCB 34714, UCB-34714, UCB34714.

Is 2(S)-[2-Oxo-4(R)-propylpyrrolidin-1-yl]butyramide classified as hazardous?

Hazard statements reported: H302, H336.

Does 2(S)-[2-Oxo-4(R)-propylpyrrolidin-1-yl]butyramide have a pharmacopoeial monograph?

Yes — a monograph exists in the European Pharmacopoeia (Ph. Eur.).

What are the key physical properties of 2(S)-[2-Oxo-4(R)-propylpyrrolidin-1-yl]butyramide?

LogP: 1.0.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.