6α-甲基-17α-羟基孕酮

Description

6α-methyl-17α-hydroxyprogesterone · CAS 520-85-4 · C22H32O3. UNII HSU1C9YRES. Melting Point: 214.5 °C.

Identification

CAS Registry Number	520-85-4
PubChem CID	10631
Molecular formula	C22H32O3
IUPAC name	(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
UNII (FDA)	HSU1C9YRES

Computed Descriptors

Molecular Weight	344.5
XLogP3	3.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	344.23514488
Monoisotopic Mass	344.23514488
Topological Polar Surface Area	54.4
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	214.5 °C

Physical description & handling notes

• Solid
• Crystals from chloroform
• Crystals from methanol; MW: 386.52. MP: 207-209 °C; specific optical rotation: +61 (in chloroform); uv max absorption (ethanol): 240 nm (epsilon = 15900). Freely soluble in ethanol, methanol; slightly soluble in ether; insoluble in water /Medroxyprogesterone 17-acetate/
• Solubility at 25 °C: in acetone 1 in 50; slightly soluble in ether and methanol; sol at 25 °C in dioxane: 1 in 60 /Medoxyprogesteron acetate/
• Very soluble in chloroform
• Stable in air. /Acetate/

GHS Hazard Classification

Reported hazard statements	H361 (92.9%)

Documented Uses

• THERAPEUTIC CATEGORY (VETERINARY): Progestogen; estrus regulator
• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Consumption (g per capita) in the USA (2002): 0.0118
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• ...Used in human medicine in US for treatment of endometriosis, habitual abortion and threatened abortion. ...in Oct 1973 US Food & Drug Administration announced plans to withdraw approval for certain strengths and vial sizes ... destined for these applications ... /Medroxyprogesterone acetate/

Synonyms

medroxyprogesterone; 520-85-4; Medroxyprogesteron; Medroxiprogesterona; Medroxyprogesteronum; Medrossiprogesterone; 6alpha-Methyl-17alpha-hydroxyprogesterone; 17-Hydroxy-6alpha-methylprogesterone; 17alpha-Hydroxy-6alpha-methylprogesterone; Farlutal inyectable; DTXSID0036508; 6alpha-Methyl-4-pregnen-17alpha-ol-3,20-dione; 17-Hydroxy-6alpha-methyl-pregn-4-ene-3,20-dione; HSU1C9YRES; U 8840; (6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione

Frequently Asked Questions

What are the CAS number and molecular formula of 6α-methyl-17α-hydroxyprogesterone?

CAS 520-85-4; molecular formula C22H32O3; molecular weight — g/mol.

What other names is 6α-methyl-17α-hydroxyprogesterone known by?

medroxyprogesterone, 520-85-4, Medroxyprogesteron, Medroxiprogesterona, Medroxyprogesteronum, Medrossiprogesterone.

Is 6α-methyl-17α-hydroxyprogesterone classified as hazardous?

Hazard statements reported: H361.

What are the key physical properties of 6α-methyl-17α-hydroxyprogesterone?

Melting Point: 214.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.