3,3',4',5-四氯水杨酰苯胺

Description

3,3',4',5-tetrachlorosalicylanilide · CAS 1154-59-2 · C13H7Cl4NO2. UNII HNE676755I. Melting Point: 161 °C.

Identification

CAS Registry Number	1154-59-2
PubChem CID	14385
Molecular formula	C13H7Cl4NO2
IUPAC name	3,5-dichloro-N-(3,4-dichlorophenyl)-2-hydroxybenzamide
UNII (FDA)	HNE676755I

Computed Descriptors

Molecular Weight	351.0
XLogP3	5.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	350.920139
Monoisotopic Mass	348.923089
Topological Polar Surface Area	49.3
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Melting Point	161 °C

Physical description & handling notes

• Crystalline solid
• Crystals
• Soluble in alkaline aqueous solutions and in solutions of wetting agents. Soluble in many organic solvents.
• When heated to decomposition it emits very toxic fumes of /chlorides and nitrogen oxides/.
• 171.2 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID4040767]
• Fluoresces under ultraviolet light

GHS Hazard Classification

Reported hazard statements	H301 (50%), H315 (50%), H319 (100%), H335 (50%)

Documented Uses

• ... as a preservative in textile finishes, certain petroleum products, cellulose esters, cutting oils, coolants
• Bacteriostat in formulations of surgical soaps, laundry soaps, rinses, polishes, shampoos, deodorants. /Former/
• Benzamide, 3,5-dichloro-N-(3,4-dichlorophenyl)-2-hydroxy-: ACTIVE
• Use in food, drugs, and cosmetics may be restricted
• The halogenated salicylanilide 3,3',4',5-tetrachlorosalicylanilide... was found to be a potent photosensitizer capable of causing disabling skin disorders. FDA directed the removal from the market of drug products containing 3,3',4',5-tetrachlorosalicylanilide in 1975.
• Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Synonyms

1154-59-2; 3,3',4',5-Tetrachlorosalicylanilide; TCSA; 3,5-Dichloro-N-(3,4-dichlorophenyl)-2-hydroxybenzamide; Irgasan BS-200; 3,5-Dichlorosalicyl-3,4-dichloroanilide; 3,5,3',4'-Tetrachlorosalicylanilide; DTXSID4040767; 3,5-Dichlorosalicyl 3,4-dichloroanilide; CHEBI:188648; HNE676755I; IRGASAN BS200; DTXCID2020767; RefChem:90620; 214-576-8; Benzamide, 3,5-dichloro-N-(3,4-dichlorophenyl)-2-hydroxy-

Frequently Asked Questions

What are the CAS number and molecular formula of 3,3',4',5-tetrachlorosalicylanilide?

CAS 1154-59-2; molecular formula C13H7Cl4NO2; molecular weight — g/mol.

What other names is 3,3',4',5-tetrachlorosalicylanilide known by?

1154-59-2, 3,3',4',5-Tetrachlorosalicylanilide, TCSA, 3,5-Dichloro-N-(3,4-dichlorophenyl)-2-hydroxybenzamide, Irgasan BS-200, 3,5-Dichlorosalicyl-3,4-dichloroanilide.

Is 3,3',4',5-tetrachlorosalicylanilide classified as hazardous?

Hazard statements reported: H301, H315, H319, H335.

What are the key physical properties of 3,3',4',5-tetrachlorosalicylanilide?

Melting Point: 161 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.